The present disclosure provides methods and compositions of hypobromous acid for use in the treatment and prevention of inflammatory conditions, acute or chronic, of infectious or noninfectious origin, such as those attributable to hypersensitivity mechanisms or trauma in human subjects and animals. The disclosure in various embodiments provides compositions prepared at the time of need for such applications so as to contain pure hypobromous acid formed from stable precursor formulations containing oxidative chlorine in the form of hypochlorous acid, hypochlorite, or other forms of aqueous oxidative chlorine.