A multiplication and addition operation device and a control method thereof are provided. The multiplication and addition operation device includes a feature information filter and an in-memory calculator. The feature information filter records a plurality of designated bits of a plurality of feature information, compares received input information with the designated bits to generate a comparison result, and generates a selected address according to the comparison result. The in-memory calculator records all bits of the feature information, and generates an operation result by performing a multiplication and addition operation on the feature information and the input information according to the selected address.