- 专利标题： METHODS AND COMPOSITIONS FOR TREATING METABOLIC IMBALANCE IN NEURODEGENERATIVE DISEASE
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申请号： US17574847申请日： 2022-01-13
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公开(公告)号： US20220257731A1公开(公告)日： 2022-08-18
- 发明人: Guangping Gao , Dominic Gessler
- 申请人： University of Massachusetts
- 申请人地址： US MA Boston
- 专利权人： University of Massachusetts
- 当前专利权人： University of Massachusetts
- 当前专利权人地址： US MA Boston
- 主分类号： A61K38/50
- IPC分类号： A61K38/50 ; A61K48/00 ; C12N15/00 ; G01N33/50 ; G01N33/06 ; A61P25/28 ; A61K9/00 ; A61K45/06 ; C12N7/00 ; G01N33/66 ; G01N33/68 ; G01N33/84
摘要：
In some aspects, the disclosure relates to compositions and methods useful for the diagnosis and treatment of neurodegenerative diseases, such as leukodystrophies (e.g., Canavan Disease). In some embodiments, the methods comprise administering to a subject an N-acetylaspartate (NAA)-depleting agent or an N-acetylaspartate (NAA)-depleting agent based upon the subject's metabolic profile.
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