Invention Application
- Patent Title: METHODS OF TREATING POMPE DISEASE
-
Application No.: US17630929Application Date: 2020-09-30
-
Publication No.: US20220273615A1Publication Date: 2022-09-01
- Inventor: Wei-Chieh CHENG , Huang-Yi LI , Wuh-Liang HWU , Yin-Hsiu CHIEN , Ni-Chung LEE
- Applicant: Academia Sinica
- Applicant Address: TW Taipei
- Assignee: Academia Sinica
- Current Assignee: Academia Sinica
- Current Assignee Address: TW Taipei
- International Application: PCT/US20/53352 WO 20200930
- Main IPC: A61K31/40
- IPC: A61K31/40 ; A61K38/47 ; A61P3/08

Abstract:
Disclosed herein are novel uses of ADMDP stereoisomers or their derivatives for the manufacture of a medicament for treating Pompe disease. Accordingly, the present disclosure provides a method of treating Pompe disease in a subject. The method includes the step of, administering to the subject a therapeutically effective amount of a compound of formula (I), or a salt, an ester or a solvate thereof, wherein R1 and R2 are independently H or alkyl optionally substituted by —NH2 or —OH, so as to ameliorate, alleviate mitigate and/or prevent symptoms associated with the Pompe disease. According to certain embodiments of the present disclosure, the compound of formula (I) may serve a stabilizer of α-glucosidase via preventing its denaturalization of deactivation.
Information query