- 专利标题： ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
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申请号： US17830650申请日： 2022-06-02
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公开(公告)号： US20220315961A1公开(公告)日： 2022-10-06
- 发明人: Haibin Chen , Steven J. Collier , Jovana Nazor , Joly Sukumaran , Derek Smith , Jeffrey C. Moore , Gregory Hughes , Jacob Janey , Gjalt W. Huisman , Scott J. Novick , Nicholas J. Agard , Oscar Alvizo , Gregory A. Cope , Wan Lin Yeo , Stefanie Ng Minor
- 申请人： CODEXIS, INC.
- 申请人地址： US CA Redwood City
- 专利权人： CODEXIS, INC.
- 当前专利权人： CODEXIS, INC.
- 当前专利权人地址： US CA Redwood City
- 主分类号： C12P13/02
- IPC分类号： C12P13/02 ; C12P13/00 ; C12P17/18 ; C12P13/04 ; C12P13/06 ; C12P17/10 ; C12P17/12 ; C12P17/16 ; C12N9/06
摘要：
The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
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