公开(公告)号：US20230295673A1

公开(公告)日：2023-09-21

申请号：US18171272

申请日：2023-02-17

申请人： CODEXIS, INC.

发明人： Haibin Chen ,  Steven J. Collier ,  Jovana Nazor ,  Joly Sukumaran ,  Derek Smith ,  Jeffrey C. Moore ,  Gregory Hughes ,  Jacob Janey ,  Gjalt W. Huisman ,  Scott J. Novick ,  Nicholas J. Agard ,  Oscar Alvizo ,  Gregory A. Cope ,  Wan Lin Yeo ,  Stefanie Ng Minor

IPC分类号： C12P13/02 ,  C12P13/00 ,  C12P17/18 ,  C12P13/04 ,  C12P13/06 ,  C12P17/10 ,  C12P17/12 ,  C12P17/16 ,  C12N9/06

CPC分类号： C12P13/02 ,  C12P13/001 ,  C12Y105/01023 ,  C12Y105/01024 ,  C12Y105/01028 ,  C12P17/185 ,  C12P17/188 ,  C12P13/04 ,  C12P13/06 ,  C12P17/10 ,  C12P17/12 ,  C12P17/165 ,  C12N9/0028 ,  C12Y105/01 ,  Y02P20/52

摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

公开(公告)号：US10947572B2

公开(公告)日：2021-03-16

申请号：US17002671

申请日：2020-08-25

申请人： CODEXIS, INC.

发明人： Haibin Chen ,  Steven J. Collier ,  Jovana Nazor ,  Joly Sukumaran ,  Derek Smith ,  Jeffrey C. Moore ,  Gregory Hughes ,  Jacob Janey ,  Gjalt W. Huisman ,  Scott J. Novick ,  Nicholas J. Agard ,  Oscar Alvizo ,  Gregory A. Cope ,  Wan Lin Yeo ,  Stefanie Ng Minor

IPC分类号： C12N9/06 ,  C12P13/02 ,  C12P17/18 ,  C12P13/04 ,  C12P13/06 ,  C12P17/10 ,  C12P17/12 ,  C12P17/16 ,  C12P13/00

摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

公开(公告)号：US20190078124A1

公开(公告)日：2019-03-14

申请号：US16195480

申请日：2018-11-19

申请人： CODEXIS, INC.

发明人： Haibin Chen ,  Steven J. Collier ,  Jovana Nazor ,  Joly Sukumaran ,  Derek Smith ,  Jeffrey C. Moore ,  Gregory Hughes ,  Jacob Janey ,  Gjalt W. Huisman ,  Scott J. Novick ,  Nicholas J. Agard ,  Oscar Alvizo ,  Gregory A. Cope ,  Wan Lin Yeo ,  Stefanie Ng Minor

IPC分类号： C12P13/02 ,  C12P17/10 ,  C12N9/06 ,  C12P17/18 ,  C12P13/04 ,  C12P13/06 ,  C12P17/12 ,  C12P17/16 ,  C12P13/00

摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

公开(公告)号：US09828614B1

公开(公告)日：2017-11-28

申请号：US15710462

申请日：2017-09-20

申请人： CODEXIS, INC.

发明人： Haibin Chen ,  Steven J. Collier ,  Jovana Nazor ,  Joly Sukumaran ,  Derek Smith ,  Jeffrey C. Moore ,  Gregory Hughes ,  Jacob Janey ,  Gjalt W. Huisman ,  Scott J. Novick ,  Nicholas J. Agard ,  Oscar Alvizo ,  Gregory A. Cope ,  Wan Lin Yeo ,  Stefanie Ng Minor

IPC分类号： C12N9/06 ,  C12P13/02 ,  C12P13/04 ,  C12P13/06 ,  C12P17/18 ,  C12P17/10 ,  C12P17/12 ,  C12P17/16 ,  C12P13/00

CPC分类号： C12P13/02 ,  C12N9/0028 ,  C12P13/001 ,  C12P13/04 ,  C12P13/06 ,  C12P17/10 ,  C12P17/12 ,  C12P17/165 ,  C12P17/185 ,  C12P17/188 ,  C12Y105/01 ,  C12Y105/01023 ,  C12Y105/01024 ,  C12Y105/01028 ,  Y02P20/52

摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

公开(公告)号：US09695451B2

公开(公告)日：2017-07-04

申请号：US15286900

申请日：2016-10-06

申请人： CODEXIS, INC.

发明人： Haibin Chen ,  Steven J. Collier ,  Jovana Nazor ,  Joly Sukumaran ,  Derek Smith ,  Jeffrey C. Moore ,  Gregory Hughes ,  Jacob Janey ,  Gjalt W. Huisman ,  Scott J. Novick ,  Nicholas J. Agard ,  Oscar Alvizo ,  Gregory A. Cope ,  Wan Lin Yeo ,  Stefanie Ng Minor

IPC分类号： C07H21/00 ,  C12N15/53 ,  C12N15/63 ,  C12P13/02 ,  C12N9/06 ,  C12P13/00 ,  C12P17/18 ,  C12P17/10 ,  C12P17/12 ,  C12P17/16 ,  C12P13/06 ,  C12P13/04

CPC分类号： C12P13/02 ,  C12N9/0028 ,  C12P13/001 ,  C12P13/04 ,  C12P13/06 ,  C12P17/10 ,  C12P17/12 ,  C12P17/165 ,  C12P17/185 ,  C12P17/188 ,  C12Y105/01 ,  C12Y105/01023 ,  C12Y105/01024 ,  C12Y105/01028 ,  Y02P20/52

摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

公开(公告)号：US10787689B2

公开(公告)日：2020-09-29

申请号：US16655547

申请日：2019-10-17

申请人： CODEXIS, INC.

发明人： Haibin Chen ,  Steven J. Collier ,  Jovana Nazor ,  Joly Sukumaran ,  Derek Smith ,  Jeffrey C. Moore ,  Gregory Hughes ,  Jacob Janey ,  Gjalt W. Huisman ,  Scott J. Novick ,  Nicholas J. Agard ,  Oscar Alvizo ,  Gregory A. Cope ,  Wan Lin Yeo ,  Stefanie Ng Minor

IPC分类号： C12N9/06 ,  C12P13/02 ,  C12P13/00 ,  C12P17/18 ,  C12P13/04 ,  C12P13/06 ,  C12P17/10 ,  C12P17/12 ,  C12P17/16

摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

公开(公告)号：US10308966B2

公开(公告)日：2019-06-04

申请号：US16195480

申请日：2018-11-19

申请人： CODEXIS, INC.

发明人： Haibin Chen ,  Steven J. Collier ,  Jovana Nazor ,  Joly Sukumaran ,  Derek Smith ,  Jeffrey C. Moore ,  Gregory Hughes ,  Jacob Janey ,  Gjalt W. Huisman ,  Scott J. Novick ,  Nicholas J. Agard ,  Oscar Alvizo ,  Gregory A. Cope ,  Wan Lin Yeo ,  Stefanie Ng Minor

IPC分类号： C12N9/06 ,  C12P13/00 ,  C12P13/02 ,  C12P13/04 ,  C12P13/06 ,  C12P17/10 ,  C12P17/12 ,  C12P17/16 ,  C12P17/18

摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

公开(公告)号：US10138503B2

公开(公告)日：2018-11-27

申请号：US15226397

申请日：2016-08-02

申请人： Codexis, Inc.

发明人： Gregory Hughes ,  Paul N. Devine ,  Fred J. Fleitz ,  Brendan T. Grau ,  John Limanto ,  Christopher Savile ,  Emily Mundorff

IPC分类号： C12P13/00 ,  C07D207/04 ,  C12P17/10 ,  C12N9/10 ,  C12P17/12 ,  C12P17/18 ,  C12P13/04

摘要： The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.

公开(公告)号：US20180187221A1

公开(公告)日：2018-07-05

申请号：US15899834

申请日：2018-02-20

申请人： CODEXIS, INC.

发明人： Haibin Chen ,  Steven J. Collier ,  Jovana Nazor ,  Joly Sukumaran ,  Derek Smith ,  Jeffrey C. Moore ,  Gregory Hughes ,  Jacob Janey ,  Gjalt W. Huisman ,  Scott J. Novick ,  Nicholas J. Agard ,  Oscar Alvizo ,  Gregory A. Cope ,  Wan Lin Yeo ,  Stefanie Ng Minor

IPC分类号： C12P13/02 ,  C12N9/06 ,  C12P13/06 ,  C12P17/18 ,  C12P13/00 ,  C12P17/16 ,  C12P17/10 ,  C12P17/12 ,  C12P13/04

CPC分类号： C12P13/02 ,  C12N9/0028 ,  C12P13/001 ,  C12P13/04 ,  C12P13/06 ,  C12P17/10 ,  C12P17/12 ,  C12P17/165 ,  C12P17/185 ,  C12P17/188 ,  C12Y105/01 ,  C12Y105/01023 ,  C12Y105/01024 ,  C12Y105/01028 ,  Y02P20/52

摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

公开(公告)号：US20180066292A1

公开(公告)日：2018-03-08

申请号：US15792446

申请日：2017-10-24

申请人： CODEXIS, INC.

发明人： Haibin Chen ,  Steven J. Collier ,  Jovana Nazor ,  Joly Sukumaran ,  Derek Smith ,  Jeffrey C. Moore ,  Gregory Hughes ,  Jacob Janey ,  Gjalt W. Huisman ,  Scott J. Novick ,  Nicholas J. Agard ,  Oscar Alvizo ,  Gregory A. Cope ,  Wan Lin Yeo ,  Stefanie Ng Minor

IPC分类号： C12P13/02 ,  C12N9/06 ,  C12P17/18 ,  C12P17/12 ,  C12P17/10 ,  C12P17/16 ,  C12P13/00 ,  C12P13/06 ,  C12P13/04

CPC分类号： C12P13/02 ,  C12N9/0028 ,  C12P13/001 ,  C12P13/04 ,  C12P13/06 ,  C12P17/10 ,  C12P17/12 ,  C12P17/165 ,  C12P17/185 ,  C12P17/188 ,  C12Y105/01 ,  C12Y105/01023 ,  C12Y105/01024 ,  C12Y105/01028 ,  Y02P20/52

摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.