A pressure distribution mapping system includes a flexible M×N textile-based pressure sensor array. with first and second electrode textile layers and a piezoresistive fabric layer with a sheet resistance of at least 60 k-ohm/square positioned between the first and second electrode textile layers. Individual pressure sensors are formed by an intersection between a row electrically-conductive path and a column electrically-conductive path along with the portion of the piezoresistive layer positioned at the intersection. A measurement system measures the resistance of each pressure sensor of the pressure sensor array. The measurement system includes a reading module with first op-amps connected to each row and second op-amps connected to each column. Plural switches switch between pressure sensor-enabled and pressure sensor-disabled positions to minimize a bus line crosstalk effect during pressure sensor reading A processor scans each pressure sensor and generates a pressure distribution profile based on a measured resistance of each pressure sensor.