A needleless connector may include a housing comprising a central longitudinal axis, a body portion, and a base portion. The body portion may include an inner surface forming an internal cavity, and a first port forming a first fluid passage to the internal cavity. The base portion may include a top section including a valve seal support, and a bottom section including a second port forming a second fluid passage to the internal cavity. The needleless connector may further include an asymmetrically-shaped valve disposed in the internal cavity. The asymmetrically-shaped valve may include a head portion, a valve body portion extending distally from the head portion, and a wall having an inner surface forming a valve cavity. The valve may be coupled with the housing such that the inner surface of the valve at the valve body portion is seated and radially supported on the valve seal support.