- 专利标题： ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4
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申请号： US17784365申请日： 2020-12-10
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公开(公告)号： US20230150986A1公开(公告)日： 2023-05-18
- 发明人: Craig W. Lindsley , P. Jeffrey Conn , Aaron M. Bender , Katrina A. Bollinger , Trever R. Carter , Jerri M. Rook , Jonathan W. Dickerson , Julie L. Engers , Kayla J. Temple , Changho Han , Matthew Spock , Logan A. Baker , Thomas M. Bridges
- 申请人： Vanderbilt University
- 申请人地址： US TN Nashville
- 专利权人： Vanderbilt University
- 当前专利权人： Vanderbilt University
- 当前专利权人地址： US TN Nashville
- 国际申请： PCT/US2020/064229 2020.12.10
- 进入国家日期： 2022-06-10
- 主分类号： C07D405/14
- IPC分类号： C07D405/14 ; C07D401/14 ; C07D403/12 ; C07D498/04 ; C07D409/14
摘要：
Disclosed herein are 2,3,5-trifluorophenyl-pyridazine substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4) Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
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