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公开(公告)号：US20170369505A1
公开(公告)日：2017-12-28
申请号：US15630200
申请日：2017-06-22
发明人： Craig W. Lindsley , P. Jeffrey Conn , Darren W. Engers , Sean Bollinger , James C. Tarr , Paul Spearing , Julie L. Engers , Madeline Long , Thomas M. Bridges
IPC分类号： C07D495/14 , C07D519/00 , C07D493/14
CPC分类号： C07D495/14 , C07D493/14 , C07D519/00
摘要： Disclosed herein are tricyclic compounds, including pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4-amine, pyrazino[2′,3′:4,5]thieno[3,2-d]pyrimidin-4-amine, pyrido[3′,2′:4,5]furo[3, 2-d]pyrimidin-4-amine, and pyrimido[4′,5′:4,5]furo[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
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公开(公告)号：US20230150986A1
公开(公告)日：2023-05-18
申请号：US17784365
申请日：2020-12-10
发明人： Craig W. Lindsley , P. Jeffrey Conn , Aaron M. Bender , Katrina A. Bollinger , Trever R. Carter , Jerri M. Rook , Jonathan W. Dickerson , Julie L. Engers , Kayla J. Temple , Changho Han , Matthew Spock , Logan A. Baker , Thomas M. Bridges
IPC分类号： C07D405/14 , C07D401/14 , C07D403/12 , C07D498/04 , C07D409/14
CPC分类号： C07D405/14 , C07D401/14 , C07D403/12 , C07D498/04 , C07D409/14 , C07B2200/05 , C07B2200/09
摘要： Disclosed herein are 2,3,5-trifluorophenyl-pyridazine substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4) Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.
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公开(公告)号：US10342782B2
公开(公告)日：2019-07-09
申请号：US15661786
申请日：2017-07-27
发明人： Craig W. Lindsley , P. Jeffrey Conn , Darren W. Engers , Carrie K. Jones , Thomas M. Bridges , Changho Han , Andrew S. Felts
IPC分类号： C07D495/14 , A61K31/4196 , A61K31/381 , A61K31/4162 , A61K31/166 , A61K31/437 , A61P25/28 , A61P25/04 , A61P25/20 , A61P25/00
摘要： Disclosed herein are thieno[3,2-e][1,2,4]triazolo[1,5-a]pyridin-6-amine, thieno[3,2-e][1,2,4]triazolo[4,3-a]pyridin-3-amine, and imidazo[1,2-a]thieno[3,2-e]pyridin-3-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
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公开(公告)号：US20190161498A1
公开(公告)日：2019-05-30
申请号：US16261108
申请日：2019-01-29
发明人： Craig W. Lindsley , P. Jeffrey Conn , Darren W. Engers , Sean Bollinger , James C. Tarr , Paul Spearing , Julie L. Engers , Madeline Long , Thomas M. Bridges
IPC分类号： C07D495/14 , C07D493/14 , C07D519/00
摘要： Disclosed herein are tricyclic compounds, including pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4-amine, pyrazino[2′,3′:4,5]thieno[3,2-d]pyrimidin-4-amine, pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-4-amine, and pyrimido[4′,5′:4,5]furo[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
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公开(公告)号：US20230348490A1
公开(公告)日：2023-11-02
申请号：US18344555
申请日：2023-06-29
发明人： Craig W. Lindsley , P. Jeffrey Conn , Darren W. Engers , Sean Bollinger , James C. Tarr , Paul Spearing , Julie L. Engers , Madeline Long , Thomas M. Bridges
IPC分类号： C07D495/14 , A61K31/519 , C07D493/14 , C07D519/00
CPC分类号： C07D495/14 , A61K31/519 , C07D493/14 , C07D519/00
摘要： Disclosed herein are tricyclic compounds, including pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4-amine, pyrazino[2′,3′:4,5]thieno[3,2-d]pyrimidin-4-amine, pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-4-amine, and pyrimido[4′,5′:4,5]furo[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
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公开(公告)号：US11142532B2
公开(公告)日：2021-10-12
申请号：US16261108
申请日：2019-01-29
发明人： Craig W. Lindsley , P. Jeffrey Conn , Darren W. Engers , Sean Bollinger , James C. Tarr , Paul Spearing , Julie L. Engers , Madeline Long , Thomas M. Bridges
IPC分类号： C07D495/14 , C07D493/14 , C07D519/00
摘要： Disclosed herein are tricyclic compounds, including pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4-amine, pyrazino[2′,3′:4,5]thieno[3,2-d]pyrimidin-4-amine, pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-4-amine, and pyrimido[4′,5′:4,5]furo[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
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公开(公告)号：US10239887B2
公开(公告)日：2019-03-26
申请号：US15630200
申请日：2017-06-22
发明人： Craig W. Lindsley , P. Jeffrey Conn , Darren W. Engers , Sean Bollinger , James C. Tarr , Paul Spearing , Julie L. Engers , Madeline Long , Thomas M. Bridges
IPC分类号： C07D491/14 , C07D495/14 , C07D493/14 , C07D519/00
摘要： Disclosed herein are tricyclic compounds, including pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4-amine, pyrazino[2′,3′:4,5]thieno[3,2-d]pyrimidin-4-amine, pyrido[3′,2′:4,5]furo[3,2-d]pyrimidin-4-amine, and pyrimido[4′,5′:4,5]furo[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
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公开(公告)号：US20180028501A1
公开(公告)日：2018-02-01
申请号：US15661786
申请日：2017-07-27
发明人： Craig W. Lindsley , P. Jeffrey Conn , Darren W. Engers , Carrie K. Jones , Thomas M. Bridges , Changho Han , Andrew S. Felts
IPC分类号： A61K31/4196 , A61K31/381 , A61K31/166 , A61K31/4162
CPC分类号： A61K31/4196 , A61K31/166 , A61K31/381 , A61K31/4162 , A61K31/437 , C07D495/14 , Y02A50/401
摘要： Disclosed herein are thieno[3,2-e][1,2,4]triazolo[1,5-a]pyridin-6-amine, thieno[3,2-e][1,2,4]triazolo[4,3-a]pyridin-3-amine, and imidazo[1,2-a]thieno[3,2-e]pyridin-3-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
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