A method, apparatus, and a computer-readable storage medium are provided for transmission power handling with RF impairments. A method, apparatus, and a computer-readable storage medium are provided for adjusting maximum power reduction (MPR) values based on transmitter and receiver impairments. transmission power handling with RF impairments. In an example implementation, the method may include determining, by a user equipment, at least a first maximum power reduction (MPR) value for a radio link, the determining based at least on one or more receiver impairments associated with a receiver of the radio link; adjusting, by the user equipment, a transmit power and a quality of a signal being transmitted on the radio link based at least on the first MPR value; and transmitting, by the user equipment, the signal using the adjusted transmit power. In another example implementation, the method may include transmitting, by a gNB, a first MPR value or a parameter indicative of the first MPR value of a radio link to a user equipment; and receiving, by the gNB, a signal from the user equipment, wherein a transmit power and a quality of the signal is adjusted at the user equipment based at least on the first MPR value.