- 专利标题： SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION
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申请号： US17920679申请日： 2021-04-20
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公开(公告)号： US20230167078A1公开(公告)日： 2023-06-01
- 发明人: Norbert SCHMEES , Ulrike ROEHN , Dennis KIRCHHOFF , Kirstin PETERSEN , Thi Thanh Uyen NGUYEN , Mareike GREES , Nicolas WERBECK , Ulf BOEMER , Benjamin BADER , Detlef STOECKIGT , Dirk KOSEMUND , Rienk OFFRINGA , Corinna LINK , Katrin NOWAK-REPPEL
- 申请人： Bayer Aktiengesellschaft , Deutsches Krebsforschungszentrum
- 申请人地址： DE Leverkusen
- 专利权人： Bayer Aktiengesellschaft,Deutsches Krebsforschungszentrum
- 当前专利权人： Bayer Aktiengesellschaft,Deutsches Krebsforschungszentrum
- 当前专利权人地址： DE Leverkusen; DE Heidelberg
- 优先权： EP 171280.9 2020.04.24
- 国际申请： PCT/EP2021/060167 2021.04.20
- 进入国家日期： 2022-10-21
- 主分类号： C07D277/46
- IPC分类号： C07D277/46 ; C07D417/06 ; C07D417/12 ; C07D487/04 ; C07D417/14 ; C07K16/28 ; C07D417/10 ; C07D471/08 ; A61P35/00
摘要：
The present invention covers aminothiazole compounds of general formula (I), in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase zeta (DGKζ) regulated disorders, as a sole agent or in combination with other active ingredients.
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