Invention Publication
- Patent Title: SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION
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Application No.: US17920679Application Date: 2021-04-20
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Publication No.: US20230167078A1Publication Date: 2023-06-01
- Inventor: Norbert SCHMEES , Ulrike ROEHN , Dennis KIRCHHOFF , Kirstin PETERSEN , Thi Thanh Uyen NGUYEN , Mareike GREES , Nicolas WERBECK , Ulf BOEMER , Benjamin BADER , Detlef STOECKIGT , Dirk KOSEMUND , Rienk OFFRINGA , Corinna LINK , Katrin NOWAK-REPPEL
- Applicant: Bayer Aktiengesellschaft , Deutsches Krebsforschungszentrum
- Applicant Address: DE Leverkusen
- Assignee: Bayer Aktiengesellschaft,Deutsches Krebsforschungszentrum
- Current Assignee: Bayer Aktiengesellschaft,Deutsches Krebsforschungszentrum
- Current Assignee Address: DE Leverkusen; DE Heidelberg
- Priority: EP 171280.9 2020.04.24
- International Application: PCT/EP2021/060167 2021.04.20
- Date entered country: 2022-10-21
- Main IPC: C07D277/46
- IPC: C07D277/46 ; C07D417/06 ; C07D417/12 ; C07D487/04 ; C07D417/14 ; C07K16/28 ; C07D417/10 ; C07D471/08 ; A61P35/00
Abstract:
The present invention covers aminothiazole compounds of general formula (I), in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase zeta (DGKζ) regulated disorders, as a sole agent or in combination with other active ingredients.
Information query
