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公开(公告)号：US20230064809A1
公开(公告)日：2023-03-02
申请号：US17780814
申请日：2020-11-24
发明人： Norbert SCHMEES , Lars WORTMANN , Dennis KIRCHHOFF , Thi Thanh Uyen NGUYEN , Nicolas WERBECK , Ulf BÖMER , Kirstin PETERSEN , Christina KOBER , Detlef STÖCKIGT , Christian LECHNER , Rienk OFFRINGA
IPC分类号： A61K31/4709 , C07D471/10 , C07D487/10 , A61K31/5377 , A61K31/496 , A61P37/04 , A61P35/00 , A61K45/06
摘要： The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8, m, n, o and p are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230201186A1
公开(公告)日：2023-06-29
申请号：US18072490
申请日：2022-11-30
发明人： Norbert SCHMEES , Lars WORTMANN , Dennis KIRCHOFF , Thi Thanh Uyen NGUYEN , Nicolas WERBECK , Ulf BÖMER , Kirstin PETERSEN , Christina KOBER , Detlef STÖCKIGT , Christian LECHNER , Robin Michael MEIER , Simon Anthony HERBERT , Isabel Patrizia KERSCHGENS , Dirk KOSEMUND , Rienk OFFRINGA , Mareike GREES
IPC分类号： A61K31/4545 , C07D401/14 , A61K31/498 , C07D413/14 , A61P37/04 , A61K31/55 , C07D401/04 , C07D405/14 , C07D417/14 , A61K31/496 , A61K31/4725 , A61P35/00 , A61K31/4709 , A61K45/06
CPC分类号： A61K31/4545 , C07D401/14 , A61K31/498 , C07D413/14 , A61P37/04 , A61K31/55 , C07D401/04 , C07D405/14 , C07D417/14 , A61K31/496 , A61K31/4725 , A61P35/00 , A61K31/4709 , A61K45/06
摘要： The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230167103A1
公开(公告)日：2023-06-01
申请号：US17921043
申请日：2021-04-20
发明人： Norbert SCHMEES , Ulrike ROEHN , Dennis KIRCHHOFF , Kirstin PETERSEN , Thi Thanh Uyen NGUYEN , Mareike GREES , Nicolas WERBECK , Ulf BOEMER , Benjamin BADER , Detlef STOECKIGT , Rienk OFFRINGA , Corinna LINK , Giambattista TESTOLIN , Katrin NOWAK-REPPEL
IPC分类号： C07D417/06 , C07D417/14 , C07K16/28 , A61P35/00
CPC分类号： C07D417/06 , C07D417/14 , C07K16/2818 , C07K16/2827 , A61P35/00
摘要： The present invention covers aminothiazole compounds of general formula (I): in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase zeta (DGKζ) regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230167078A1
公开(公告)日：2023-06-01
申请号：US17920679
申请日：2021-04-20
发明人： Norbert SCHMEES , Ulrike ROEHN , Dennis KIRCHHOFF , Kirstin PETERSEN , Thi Thanh Uyen NGUYEN , Mareike GREES , Nicolas WERBECK , Ulf BOEMER , Benjamin BADER , Detlef STOECKIGT , Dirk KOSEMUND , Rienk OFFRINGA , Corinna LINK , Katrin NOWAK-REPPEL
IPC分类号： C07D277/46 , C07D417/06 , C07D417/12 , C07D487/04 , C07D417/14 , C07K16/28 , C07D417/10 , C07D471/08 , A61P35/00
CPC分类号： C07D277/46 , C07D417/06 , C07D417/12 , C07D487/04 , C07D417/14 , C07K16/2818 , C07K16/2827 , C07D417/10 , C07D471/08 , A61P35/00 , C07B2200/07
摘要： The present invention covers aminothiazole compounds of general formula (I), in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase zeta (DGKζ) regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230148194A1
公开(公告)日：2023-05-11
申请号：US17780890
申请日：2020-11-24
发明人： Norbert SCHMEES , Lars WORTMANN , DENNIS KIRCHHOFF , Thi Thanh Uyen NGUYEN , Nicolas WERBECK , Ulf BÖMER , Kirstin PETERSEN , Christina KOBER , Detlef STÖCKIGT , Christian LECHNER , Robin Michael MEIER , Simon Anthony HERBERT , Isabel Patrizia KERSCHGENS , DIRK KOSEMUND , Rienk OFFRINGA , Mareike GREES
IPC分类号： A61K31/4545 , C07D413/14 , C07D401/14 , C07D401/04 , C07D417/14 , C07D405/14 , A61K31/4709 , A61K31/496 , A61K31/4725 , A61K31/498 , A61K31/55 , A61K45/06 , A61P35/00 , A61P37/04
CPC分类号： A61K31/4545 , C07D413/14 , C07D401/14 , C07D401/04 , C07D417/14 , C07D405/14 , A61K31/4709 , A61K31/496 , A61K31/4725 , A61K31/498 , A61K31/55 , A61K45/06 , A61P35/00 , A61P37/04
摘要： The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230062100A1
公开(公告)日：2023-03-02
申请号：US17780903
申请日：2020-11-24
发明人： Norbert SCHMEES , Lars WORTMANN , DENNIS KIRCHOFF , Thi Thanh Uyen NGUYEN , Nicolas WERBECK , Ulf BÖMER , Kirstin PETERSEN , Christina KOBER , Detlef STÖCKIGT , Christian LECHNER , Robin Michael MEIER , Simon Anthony HERBERT , Isabel Patrizia KERSCHGENS , DIRK KOSEMUND , Julien LEFRANC , Rienk OFFRINGA
IPC分类号： A61K31/4709 , C07D401/04 , C07D401/14 , C07D413/14 , C07D405/14 , C07F9/6558 , C07D417/14 , A61K31/513 , A61K31/496 , A61K31/506 , A61K31/675 , A61K31/55 , A61P37/04 , A61P35/00 , A61K45/06
摘要： The present invention covers aminoquinolone compounds of general formula (I): in which R1, R2, R3, R4, R5, R6, R7, R8, X and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
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