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公开(公告)号：US20230167103A1
公开(公告)日：2023-06-01
申请号：US17921043
申请日：2021-04-20
发明人： Norbert SCHMEES , Ulrike ROEHN , Dennis KIRCHHOFF , Kirstin PETERSEN , Thi Thanh Uyen NGUYEN , Mareike GREES , Nicolas WERBECK , Ulf BOEMER , Benjamin BADER , Detlef STOECKIGT , Rienk OFFRINGA , Corinna LINK , Giambattista TESTOLIN , Katrin NOWAK-REPPEL
IPC分类号： C07D417/06 , C07D417/14 , C07K16/28 , A61P35/00
CPC分类号： C07D417/06 , C07D417/14 , C07K16/2818 , C07K16/2827 , A61P35/00
摘要： The present invention covers aminothiazole compounds of general formula (I): in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase zeta (DGKζ) regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230167078A1
公开(公告)日：2023-06-01
申请号：US17920679
申请日：2021-04-20
发明人： Norbert SCHMEES , Ulrike ROEHN , Dennis KIRCHHOFF , Kirstin PETERSEN , Thi Thanh Uyen NGUYEN , Mareike GREES , Nicolas WERBECK , Ulf BOEMER , Benjamin BADER , Detlef STOECKIGT , Dirk KOSEMUND , Rienk OFFRINGA , Corinna LINK , Katrin NOWAK-REPPEL
IPC分类号： C07D277/46 , C07D417/06 , C07D417/12 , C07D487/04 , C07D417/14 , C07K16/28 , C07D417/10 , C07D471/08 , A61P35/00
CPC分类号： C07D277/46 , C07D417/06 , C07D417/12 , C07D487/04 , C07D417/14 , C07K16/2818 , C07K16/2827 , C07D417/10 , C07D471/08 , A61P35/00 , C07B2200/07
摘要： The present invention covers aminothiazole compounds of general formula (I), in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase zeta (DGKζ) regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20230139936A1
公开(公告)日：2023-05-04
申请号：US17944922
申请日：2022-09-14
发明人： Norbert SCHMEES , Ulrike ROEHN , Dennis KIRCHHOFF , Kirstin PETERSEN , Mareike GREES , Nicolas WERBECK , Benjamin BADER , Rienk OFFRINGA , Corinna LINK
IPC分类号： C07D277/42 , A61P35/00
摘要： The present invention covers aminothiazole compounds of general formula (I), in which R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase zeta (DGKζ) regulated disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20200237757A1
公开(公告)日：2020-07-30
申请号：US16303539
申请日：2017-05-23
发明人： Norbert SCHMEES , Ilona GUTCHER , Horst IRLBACHER , Benjamin BADER , Na ZHAO , Michael PLATTEN , Ulrike ROEHN , Ludwig ZORN , Lars ROESE , Detlef STOECKIGT
IPC分类号： A61K31/501 , A61K45/06 , C07D237/24 , C07D405/12 , C07D403/12 , A61K31/50 , A61P35/00
摘要： The present invention covers 3-oxo-2,6-diphenyl-2,3-dihydropyridazine-4-carboxamide compounds of general formula (I): in which R1, R2, R3, R4, R5 and R6 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of cancer or conditions with 10 dysregulated immune responses or other disorders associated with aberrant AHR signaling, as a sole agent or in combination with other active ingredients.
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