- 专利标题： DIHYDROOXADIAZINONES
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申请号： US17862255申请日： 2022-07-11
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公开(公告)号： US20230017200A1公开(公告)日： 2023-01-19
- 发明人: Manuel ELLERMANN , Stefan Nikolaus GRADL , Charlotte Christine KOPITZ , Martin LANGE , Adrian TERSTEEGEN , Philip LIENAU , Christa HEGELE-HARTUNG , Detlev SÜLZLE , Timothy A. LEWIS , Heidi GREULICH , Xiaoyun WU , Matthew MEYERSON , Alex BURGIN
- 申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.
- 申请人地址： DE Leverkusen; DE Berlin; US MA Cambridge; US MA Boston
- 专利权人： Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft,The Broad Institute, Inc.,Dana-Farber Cancer Institute, Inc.
- 当前专利权人： Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft,The Broad Institute, Inc.,Dana-Farber Cancer Institute, Inc.
- 当前专利权人地址： DE Leverkusen; DE Berlin; US MA Cambridge; US MA Boston
- 主分类号： C07D273/04
- IPC分类号： C07D273/04 ; C07D413/10 ; C07D413/12 ; C07D417/10 ; C07D471/04 ; C07D491/107 ; C07D495/10
摘要：
The present invention provides dihydrooxydiazinone compounds of general formula (I): in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
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