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公开(公告)号：US20220396554A1
公开(公告)日：2022-12-15
申请号：US17865236
申请日：2022-07-14
申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.
发明人： Manuel ELLERMANN , Stefan Nikolaus GRADL , Charlotte Christine KOPITZ , Martin LANGE , Adrian TERSTEEGEN , Philip LIENAU , Christa HEGELE-HARTUNG , Detlev SÜLZLE , Timothy A. LEWIS , Heidi GREULICH , Xiaoyun WU , Matthew MEYERSON , Alex BURGIN
IPC分类号： C07D273/04 , C07D413/10 , C07D413/12 , C07D417/10 , C07D471/04 , C07D491/107 , C07D495/10
摘要： The present invention provides dihydrooxydiazinone compounds of general formula (I) in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
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2.发明公开公开(公告)号：US20240182452A1
公开(公告)日：2024-06-06
申请号：US18399092
申请日：2023-12-28
申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.
发明人： Manuel ELLERMANN , Stefan Nikolaus GRADL , Charlotte Christine KOPITZ , Martin LANGE , Adrian TERSTEEGEN , Philip LIENAU , Detlev SÜLZLE , Timothy LEWIS , Heidi GREULICH , Xiaoyun WU , Matthew MEYERSON
IPC分类号： C07D403/10 , A61P35/04 , C07D237/04 , C07D401/10 , C07D405/10 , C07D413/10
CPC分类号： C07D403/10 , A61P35/04 , C07D237/04 , C07D401/10 , C07D405/10 , C07D413/10
摘要： The present invention provides dihydropyridazinone compounds of general formula (I)
in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.-
公开(公告)号：US20230017200A1
公开(公告)日：2023-01-19
申请号：US17862255
申请日：2022-07-11
申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc.
发明人： Manuel ELLERMANN , Stefan Nikolaus GRADL , Charlotte Christine KOPITZ , Martin LANGE , Adrian TERSTEEGEN , Philip LIENAU , Christa HEGELE-HARTUNG , Detlev SÜLZLE , Timothy A. LEWIS , Heidi GREULICH , Xiaoyun WU , Matthew MEYERSON , Alex BURGIN
IPC分类号： C07D273/04 , C07D413/10 , C07D413/12 , C07D417/10 , C07D471/04 , C07D491/107 , C07D495/10
摘要： The present invention provides dihydrooxydiazinone compounds of general formula (I): in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20210353630A1
公开(公告)日：2021-11-18
申请号：US17389940
申请日：2021-07-30
发明人： Stefan Nikolaus GRADL , Manuel ELLERMANN , Philip LIENAU , Charlotte Christine KOPITZ , Martin LANGE , Adrian TERSTEEGEN , Detlev SÜLZLE , Timothy A. LEWIS , Heidi GREULICH , Xiaoyun WU
IPC分类号： A61K31/53 , A61P35/00 , C07D403/10 , C07D403/12 , C07D253/06
摘要： The present invention includes name compounds of general formula (I): (I) in which R1, R2, R3 and R4 are as defined herein, methods for their preparation, pharmaceutical compositions and combinations comprising said compounds, and their use for the treatment of hyperproliferative diseases.
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公开(公告)号：US20240010684A1
公开(公告)日：2024-01-11
申请号：US18035493
申请日：2021-10-29
发明人： Donald BIERER , Ingo FLAMME , Dmitry ZUBOV , Thomas NEUBAUER , Adrian TERSTEEGEN , Lars BAUMANN , Cathleen JUHL , Marie GLATZ , Jan DREHER , Simon HOLTON , Jiancheng XIONG , Jianchao XU
摘要： The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory bicyclic compounds, as well as to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.
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公开(公告)号：US20210246166A1
公开(公告)日：2021-08-12
申请号：US17138447
申请日：2020-12-30
发明人： Donald BIERER , Ingo FLAMME , Dmitry ZUBOV , Thomas NEUBAUER , Adrian TERSTEEGEN , Cathleen JUHL , Marie GLATZ , Jan DREHER , Simon HOLTON , Carsten TERJUNG , Lars BAUMANN , Thorsten POETHKO , Jiancheng XIONG , Yibo QIU
摘要： The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.
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公开(公告)号：US20220144848A1
公开(公告)日：2022-05-12
申请号：US17416274
申请日：2019-12-18
发明人： Susanne ROEHRIG , Sebastian ESSIG , Pascal ELLERBROCK , Sonja ANLAUF , Thomas NEUBAUER , Alexander HILLISCH , Katharina MEIER , Stefan HEITMEIER , Adrian TERSTEEGEN , Martina SCHAFER , Jan STAMPFUSS , Dieter LANG , Eloisa JIMENEZ NUNEZ , Jens ACKERSTAFF , Henrik TELLER , Zengqiang ZOU , Ping LIU , Xianghai MENG , Frank LESSMANN
IPC分类号： C07D491/044
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular vascular disorders, preferably thrombotic or thromboembolic disorders and/or thrombotic or thromboembolic complications.
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公开(公告)号：US20170233413A1
公开(公告)日：2017-08-17
申请号：US15503448
申请日：2015-08-25
发明人： Walter HÜBSCH , Alexandros VAKALOPOULOS , Markus FOLLMANN , Gaelle VALOT , Johannes-Peter STASCH , Damian BROCKSCHNIEDER , Tobias MARQUARDT , Frank WUNDER , Adrian TERSTEEGEN , Lisa DIETZ , Dieter LANG , Niels LINDNER
IPC分类号： C07D519/00 , C07D487/04 , A61K9/08 , A61K31/519 , A61K9/20 , A61K9/00
CPC分类号： C07D519/00 , A61K9/0053 , A61K9/08 , A61K9/20 , A61K31/519 , C07D471/04 , C07D487/04
摘要： The present application relates to novel substituted fused pyrimidines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.
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公开(公告)号：US20170020875A1
公开(公告)日：2017-01-26
申请号：US15288982
申请日：2016-10-07
发明人： Chantal FÜRSTNER , Jens ACKERSTAFF , Alexander STRAUB , Heinrich MEIER , Hanna TINEL , Katja ZIMMERMANN , Adrian TERSTEEGEN , Dmitry ZUBOV , Raimund KAST , Jens SCHAMBERGER , Martina SCHÄFER , Kirsten BÖRNGEN
IPC分类号： A61K31/506 , A61K45/06 , C07D405/14 , C07D413/04 , A61K31/538 , C07D401/04 , A61K31/536 , C07D409/14 , C07D417/14 , C07D403/04 , C07D417/04
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
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公开(公告)号：US20160272637A1
公开(公告)日：2016-09-22
申请号：US15032212
申请日：2014-10-28
发明人： Susanne RÖHRIG , Alexander HILLISCH , Julia STRASSBURGER , Stefan HEITMEIER , Martina Victoria SCHMIDT , Karl-Heinz SCHLEMMER , Adrian TERSTEEGEN , Anja BUCHMÜLLER , Christoph GERDES , Martina SCHÄFER , Henrik TELLER , Eloisa JIMENEZ NUNEZ , Hartmut SCHIROK , Jürgen KLAR
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及眼药水以及眼科疾病的药物的用途 。
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