- 专利标题： Cocktail Vaccine of Recombinant African Swine Fever Virus (ASFV) Antigen and Use Thereof
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申请号： US17948752申请日： 2022-09-20
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公开(公告)号： US20230218736A1公开(公告)日： 2023-07-13
- 发明人: Junjun SHAO , Guanglei ZHANG , Wei LIU , Xiaxia LIANG , Huiyun CHANG
- 申请人： Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
- 申请人地址： CN Lanzhou
- 专利权人： Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
- 当前专利权人： Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
- 当前专利权人地址： CN GS Lanzhou
- 优先权： CN 2210024618.6 2022.01.11
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; C07K14/005 ; A61K39/295 ; A61P31/20
摘要：
The present disclosure relates to a cocktail vaccine of a recombinant African swine fever virus (ASFV) antigen and use thereof, and belongs to the field of biotechnology pharmacy. The cocktail vaccine is prepared by combination of recombinant proteins p30-modified p54, p72 epitope-N-segment amino acid sequence of pE248R, and N-terminal amino acid sequence of CD2v-C-terminal amino acid sequence of pEP153R with an adjuvant. The present disclosure provides a method for expressing and purifying the three recombinant proteins, as well as a ratio of each recombinant protein and the adjuvant for preparing the cocktail vaccine.
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