- 专利标题： TUMOR THERAPY COMPOSITIONS AND METHODS
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申请号： US17625896申请日： 2020-07-17
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公开(公告)号： US20230285456A1公开(公告)日： 2023-09-14
- 发明人: Fu-Sen Liang , Wei Wang , Judy Cannon , Alex Huang , Huong Nguyen
- 申请人： Fu-Sen Liang , Wei Wang , Judy Cannon , Alex Huang , Huong Nguyen , UNM RAINFOREST INNOVATIONS , CASE WESTERN RESERVE UNIVERSITY
- 申请人地址： US NM Albuquerque
- 专利权人： Fu-Sen Liang,Wei Wang,Judy Cannon,Alex Huang,Huong Nguyen,UNM RAINFOREST INNOVATIONS,CASE WESTERN RESERVE UNIVERSITY
- 当前专利权人： Fu-Sen Liang,Wei Wang,Judy Cannon,Alex Huang,Huong Nguyen,UNM RAINFOREST INNOVATIONS,CASE WESTERN RESERVE UNIVERSITY
- 当前专利权人地址： US NM Albuquerque
- 国际申请： PCT/US2020/042508 2020.07.17
- 进入国家日期： 2022-01-10
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; C12N15/62 ; A61P35/00 ; A61K47/66 ; A61K38/17
摘要：
A modified T cell includes exogenous polynucleotides that encode components of a therapeutic expression system. A first exogenous polynucleotide encodes a therapeutic polypeptide operably linked to a regulatory region inducible by inducer. A second exogenous polynucleotide encodes polypeptide components of a chemical induced proximity (CIP) complex. A third exogenous polynucleotide that encodes a chimeric antigen receptor that specifically binds to an antigen.
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