Various embodiments disclosed herein relate to hardware enabled pipeline control. In a hardware acceleration system, pipelines are configured to include a hardware enable flag that allows hardware initiation of the pipeline based on triggering of a configurable event. The pipeline can be configured to set the event that triggers the initiation of the pipeline. For example, the end of pipeline of a first pipeline may trigger the initiation of a second pipeline. Accordingly, pipelines that are configured to allow hardware enable based on a specifically configured event are not subject to the extra processing required to initiate the pipeline via software in external memory and triggered by an external controller.