- 专利标题： PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS
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申请号： US17674237申请日： 2022-02-17
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公开(公告)号： US20230043959A1公开(公告)日： 2023-02-09
- 发明人: Taisheng Huang , Chu-Biao Xue , Hui-Yin Li , Qun Li , Anlai Wang , Lingquan Kong , Hai Fen Ye , Wenqing Yao , James D. Rodgers , Stacey Shepard , Haisheng Wang , Lixin Shao
- 申请人： Incyte Corporation , Incyte Holdings Corporation
- 申请人地址： US DE Wilmington; US DE Wilmington
- 专利权人： Incyte Corporation,Incyte Holdings Corporation
- 当前专利权人： Incyte Corporation,Incyte Holdings Corporation
- 当前专利权人地址： US DE Wilmington; US DE Wilmington
- 主分类号： A61K31/4545
- IPC分类号： A61K31/4545 ; C07D487/04 ; A61P1/00 ; A61P11/00 ; A61P35/00 ; A61P11/06 ; A61P27/02 ; A61P17/04 ; A61P37/06 ; C07D401/14 ; C07D405/14 ; A61K9/00 ; A61K31/519
摘要：
The present invention provides piperidin-4-y1 azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
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