公开(公告)号：US10695337B2

公开(公告)日：2020-06-30

申请号：US15995323

申请日：2018-06-01

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Taisheng Huang ,  Chu-Biao Xue

IPC分类号： A61K31/519 ,  A61P17/04 ,  A61K31/4545 ,  C07D487/04 ,  A61P1/00 ,  A61P11/00 ,  A61P35/00 ,  A61P11/06 ,  A61P27/02 ,  C07D401/14 ,  C07D405/14 ,  A61K9/00 ,  C07D519/00 ,  C07D471/04

摘要： The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

公开(公告)号：US20200155527A1

公开(公告)日：2020-05-21

申请号：US16685183

申请日：2019-11-15

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Chu-Biao Xue ,  Yun-Long Li ,  Hao Feng ,  Jun Pan ,  Anlai Wang ,  Ke Zhang ,  Wenqing Yao ,  Fenglei Zhang ,  Jincong Zhuo

IPC分类号： A61K31/444 ,  C07D491/048 ,  C07D471/04 ,  C07D417/14 ,  C07D405/14 ,  C07D401/14 ,  C07D495/04

摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

公开(公告)号：US20180193323A1

公开(公告)日：2018-07-12

申请号：US15815255

申请日：2017-11-16

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Chu-Biao Xue ,  Yun-Long Li ,  Hao Feng ,  Jun Pan ,  Anlai Wang ,  Ke Zhang ,  Wenqing Yao ,  Fenglei Zhang ,  Jincong Zhuo

IPC分类号： A61K31/444 ,  C07D495/04 ,  C07D491/048 ,  C07D401/14 ,  C07D417/14 ,  C07D405/14 ,  C07D471/04

CPC分类号： A61K31/444 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

公开(公告)号：US09550765B2

公开(公告)日：2017-01-24

申请号：US14811038

申请日：2015-07-28

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Chu-Biao Xue ,  Yun-Long Li ,  Hao Feng ,  Ke Zhang ,  Wenqing Yao

IPC分类号： A61K31/444 ,  C07D471/04 ,  C07D495/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D491/048

CPC分类号： A61K31/444 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

摘要翻译： 本公开描述了噻唑和吡啶甲酰胺衍生物，其组合物和使用方法。 所述化合物抑制Pim激酶的活性，并且可用于治疗与Pim激酶的活性相关的疾病，包括例如癌症和其它疾病。

公开(公告)号：US20150329534A1

公开(公告)日：2015-11-19

申请号：US14811038

申请日：2015-07-28

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Chu-Biao Xue ,  Yun-Long Li ,  Hao Feng ,  Jun Pan ,  Anlai Wang ,  Ke Zhang ,  Wenqing Yao ,  Fenglei Zhang ,  Jincong Zhuo

IPC分类号： C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

CPC分类号： A61K31/444 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

摘要翻译： 本公开描述了噻唑和吡啶甲酰胺衍生物，其组合物和使用方法。 所述化合物抑制Pim激酶的活性，并且可用于治疗与Pim激酶的活性相关的疾病，包括例如癌症和其它疾病。

公开(公告)号：US10517858B2

公开(公告)日：2019-12-31

申请号：US16298601

申请日：2019-03-11

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Chu-Biao Xue ,  Yun-Long Li ,  Hao Feng ,  Ke Zhang

IPC分类号： A61K31/444 ,  C07D495/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048

摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

公开(公告)号：US20190209537A1

公开(公告)日：2019-07-11

申请号：US16298601

申请日：2019-03-11

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Chu-Biao Xue ,  Yun-Long Li ,  Hao Feng ,  Jun Pan ,  Anlai Wang ,  Ke Zhang ,  Wenqing Yao ,  Fenglei Zhang ,  Jincong Zhuo

IPC分类号： A61K31/444 ,  C07D491/048 ,  C07D471/04 ,  C07D495/04 ,  C07D405/14 ,  C07D401/14 ,  C07D417/14

摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

公开(公告)号：US09849120B2

公开(公告)日：2017-12-26

申请号：US15373923

申请日：2016-12-09

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Chu-Biao Xue ,  Yun-Long Li ,  Hao Feng ,  Ke Zhang

IPC分类号： A61K31/444 ,  C07D405/14 ,  C07D495/04 ,  C07D471/04 ,  C07D491/048 ,  C07D401/14 ,  C07D417/14

CPC分类号： A61K31/444 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04

摘要： The present disclosure describes thiazole and pyridine carboxamide derivatives, their compositions and methods of use. The compounds inhibit the activity of the Pim kinases and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

公开(公告)号：US09676750B2

公开(公告)日：2017-06-13

申请号：US15001826

申请日：2016-01-20

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Yun-Long Li ,  David M. Burns ,  Hao Feng ,  Chu-Biao Xue ,  Anlai Wang ,  Jun Pan

IPC分类号： C07D471/02 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D498/04 ,  C07D491/048 ,  C07D498/22

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/048 ,  C07D498/04 ,  C07D498/22

摘要： The present disclosure describes bicyclic aromatic carboxamide derivatives, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

公开(公告)号：US09278950B2

公开(公告)日：2016-03-08

申请号：US14155134

申请日：2014-01-14

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Yun-Long Li ,  David M. Burns ,  Hao Feng ,  Chu-Biao Xue ,  Anlai Wang ,  Jun Pan

IPC分类号： C07D471/02 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D498/04 ,  C07D491/048

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04 ,  C07D491/048 ,  C07D498/04 ,  C07D498/22

摘要： The present disclosure describes bicyclic aromatic carboxamide derivatives, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.

摘要翻译： 本公开描述了双环芳族羧酰胺衍生物，以及它们的组合物和使用方法。 该化合物抑制Pim激酶的活性，并且可用于治疗与Pim激酶活性相关的疾病，包括例如癌症和其它疾病。