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公开(公告)号：US20200002341A1
公开(公告)日：2020-01-02
申请号：US16436195
申请日：2019-06-10
发明人： Jiacheng Zhou , James D. Rodgers , Haisheng Wang
IPC分类号： C07D487/04 , C07F7/18 , C07F7/10 , C07F5/02 , C07F7/08
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
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![N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors](/abs-image/US/2016/05/10/US09334274B2/abs.jpg.150x150.jpg)
2.发明授权N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors 有权吡唑-4-基 - 吡咯并[2,3-d]嘧啶和吡咯-3-基 - 吡咯并[2,3-d]嘧啶的N-（杂）芳基 - 吡咯烷衍生物作为甘蔗激酶抑制剂公开(公告)号：US09334274B2
公开(公告)日：2016-05-10
申请号：US14250843
申请日：2014-04-11
发明人： James D Rodgers , Stacey Shepard , Argyrios G Arvanitis , Haisheng Wang , Louis Storace , Beverly Folmer , Wenyu Zhu , Joseph Glenn , Lixin Shao
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04 , C07D519/00 , C07D471/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D487/04 , C07D471/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
摘要翻译： 本发明涉及式I的N-（杂）芳基 - 吡咯烷衍生物：其是JAK抑制剂，例如选择性JAK1抑制剂，其可用于治疗JAK相关疾病，包括例如炎性和自身免疫性疾病，以及 作为癌症。
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公开(公告)号：US10975085B2
公开(公告)日：2021-04-13
申请号：US16436195
申请日：2019-06-10
发明人： Jiacheng Zhou , James D. Rodgers , Haisheng Wang
IPC分类号： C07D487/04 , C07F7/18 , C07F7/10 , C07F5/02 , C07F7/08
摘要： The present invention is related to processes for preparing a composition comprising (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile, and related synthetic intermediate compounds. This compound is useful as an inhibitor of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
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![Processes for preparing 4-chloro-7H-pyrrolo[2,3-d]pyrimidine](/abs-image/US/2019/07/30/US10364248B2/abs.jpg.150x150.jpg)
公开(公告)号：US10364248B2
公开(公告)日：2019-07-30
申请号：US15869650
申请日：2018-01-12
发明人： Jiacheng Zhou , James D. Rodgers , Haisheng Wang
IPC分类号： C07D487/04 , C07F7/18 , C07F7/10 , C07F5/02 , C07F7/08
摘要： The present invention is related to processes for preparing 4-chloro-7H-pyrollo[2,3,-d]pyrimidine, and related synthetic intermediate compounds. 4-Chloro-7H-pyrrolo[2,3,-d]pyrimidine is an intermediate for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines, which are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
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![Pyrrolo[2,3-b]pyridin-4-yl-amines and pyrrolo[2,3-b] pyrimidin-5-yl-amines as Janus kinase inhibitors](/abs-image/US/2018/01/30/US09879010B2/abs.jpg.150x150.jpg)
公开(公告)号：US09879010B2
公开(公告)日：2018-01-30
申请号：US15409085
申请日：2017-01-18
IPC分类号： C07D401/02 , A61K31/437 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.
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公开(公告)号：US20230043959A1
公开(公告)日：2023-02-09
申请号：US17674237
申请日：2022-02-17
发明人： Taisheng Huang , Chu-Biao Xue , Hui-Yin Li , Qun Li , Anlai Wang , Lingquan Kong , Hai Fen Ye , Wenqing Yao , James D. Rodgers , Stacey Shepard , Haisheng Wang , Lixin Shao
IPC分类号： A61K31/4545 , C07D487/04 , A61P1/00 , A61P11/00 , A61P35/00 , A61P11/06 , A61P27/02 , A61P17/04 , A61P37/06 , C07D401/14 , C07D405/14 , A61K9/00 , A61K31/519
摘要： The present invention provides piperidin-4-y1 azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
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公开(公告)号：US20210253584A1
公开(公告)日：2021-08-19
申请号：US17176914
申请日：2021-02-16
发明人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , Brian W. Metcalf , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , James D. Rodgers , Haisheng Wang
IPC分类号： C07D487/04 , C07F7/18 , C07F7/10 , C07F5/02 , C07F7/08
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
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![Processes for preparing pyrazolyl-substituted pyrrolo[2,3-d]pyrimidines](/abs-image/US/2018/03/06/US09908888B2/abs.jpg.150x150.jpg)
公开(公告)号：US09908888B2
公开(公告)日：2018-03-06
申请号：US15016918
申请日：2016-02-05
发明人： Jiacheng Zhou , Pingli Liu , Qiyan Lin , Brian W. Metcalf , David Meloni , Yongchun Pan , Michael Xia , Mei Li , Tai-Yuen Yue , James D. Rodgers , Haisheng Wang
IPC分类号： C07D487/04 , C07D231/10 , C07F7/18 , C07F7/10 , C07F5/02 , C07F7/08
CPC分类号： C07D487/04 , C07F5/025 , C07F7/083 , C07F7/10 , C07F7/1892 , Y02P20/55
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
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公开(公告)号：US20180353499A1
公开(公告)日：2018-12-13
申请号：US15995323
申请日：2018-06-01
发明人： Taisheng Huang , Chu-Biao Xue , Hui-Yin Li , Qun Li , Anlai Wang , Lingquan Kong , Hai Fen Ye , Wenqing Yao , James D. Rodgers , Stacey Shepard , Haisheng Wang , Lixin Shao
IPC分类号： A61K31/4545 , C07D487/04 , A61P11/06 , A61P1/00 , A61P27/02 , C07D405/14 , C07D401/14 , A61K31/519 , A61K9/00 , A61P35/00 , A61P11/00 , C07D471/04 , C07D519/00
摘要： The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
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![PYRROLO[2,3-B]PYRIDIN-4-YL-AMINES AND PYRROLO[2,3-B]PYRIMIDIN-5-YL-AMINES AS JANUS KINASE INHIBITORS](/abs-image/US/2017/12/07/US20170349579A1/abs.jpg.150x150.jpg)
10.发明申请公开(公告)号：US20170349579A1
公开(公告)日：2017-12-07
申请号：US15409085
申请日：2017-01-18
IPC分类号： C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.
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