A vehicular driver monitoring system includes an interior rearview mirror assembly having a driver monitoring camera and first and second near-infrared light emitting elements accommodated by a mirror head. The light emitting elements are oriented at the mirror head so that (i) a beam of light emitted by the first light emitting element would be directed toward a driver's region of a left hand drive vehicle if the mirror assembly were installed in the LHD vehicle, and (ii) a beam of light emitted by the second light emitting element would be directed toward a driver's region of a right hand drive vehicle if the mirror assembly were installed in the RHD vehicle. The system enables and/or operates the first or second light emitting element for a driver monitoring function responsive to indication that the mirror assembly is installed or will be installed in a LHD vehicle or a RHD vehicle.