- 专利标题： THYROID HORMONE RECEPTOR b SELECTIVE AGONIST COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF
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申请号： US18267298申请日： 2021-12-10
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公开(公告)号： US20240059676A1公开(公告)日： 2024-02-22
- 发明人: Bing Zhou , Ying Leng , Yaxi Yang , Mengmeng Ning , Liuyu Hu , Lei Feng , Ju Liang
- 申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- 申请人地址： CN Shanghai
- 专利权人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- 当前专利权人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- 当前专利权人地址： CN Shanghai
- 优先权： CN 2011478971.9 2020.12.15 CN 2111482622.9 2021.12.07
- 国际申请： PCT/CN2021/136993 2021.12.10
- 进入国家日期： 2023-06-14
- 主分类号： C07D403/10
- IPC分类号： C07D403/10 ; C07D413/10 ; C07D471/04 ; A61P3/06
摘要：
The present invention relates to a thyroid hormone receptor β selective agonist compound represented by formula I, a pharmaceutical composition and use thereof. The compound improves the selectivity to THR-α and the druggability of the compound while maintaining good THR-β agonistic activity, and shows a certain activity in in vivo pharmacological experiments.
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