专利检索 ap:("SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES") AND inv:"Ju Liang" 第 1 页

1.

发明公开
THYROID HORMONE RECEPTOR b SELECTIVE AGONIST COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF 审中-公开

公开(公告)号：US20240059676A1

公开(公告)日：2024-02-22

申请号：US18267298

申请日：2021-12-10

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Bing Zhou , Ying Leng , Yaxi Yang , Mengmeng Ning , Liuyu Hu , Lei Feng , Ju Liang

IPC分类号： C07D403/10 , C07D413/10 , C07D471/04 , A61P3/06

CPC分类号： C07D403/10 , C07D413/10 , C07D471/04 , A61P3/06

摘要： The present invention relates to a thyroid hormone receptor β selective agonist compound represented by formula I, a pharmaceutical composition and use thereof. The compound improves the selectivity to THR-α and the druggability of the compound while maintaining good THR-β agonistic activity, and shows a certain activity in in vivo pharmacological experiments.