- 专利标题： pHLIP® peptide mediated epitope tethering at cell surfaces
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申请号： US18325884申请日： 2023-05-30
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公开(公告)号： US20240066096A1公开(公告)日： 2024-02-29
- 发明人: Yana K. RESHETNYAK , Oleg A. ANDREEV , Anna MOSHNIKOVA , Donald M. Engelman
- 申请人： UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES , YALE UNIVERSITY
- 申请人地址： US RI Kingston
- 专利权人： UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES,YALE UNIVERSITY
- 当前专利权人： UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES,YALE UNIVERSITY
- 当前专利权人地址： US RI Kingston
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; A61K38/19 ; A61K38/20
摘要：
The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIP● construct comprising an antibody recruiting molecule linked to one or more pHLIP● peptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.
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