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公开(公告)号：US20240342296A1
公开(公告)日：2024-10-17
申请号：US18608699
申请日：2024-03-18
IPC分类号： A61K47/64 , A61K9/00 , A61K31/4745 , A61K31/5386 , A61K31/7036 , A61K38/12 , A61K47/60 , A61P35/00
CPC分类号： A61K47/6425 , A61K9/0014 , A61K9/0034 , A61K31/4745 , A61K31/5386 , A61K31/7036 , A61K38/12 , A61K47/60 , A61K47/6415 , A61P35/00
摘要： The invention features a composition comprising a potent cytotoxic compound and a pHILIP® peptide, where, e.g., the cytotoxic compound cannot be used alone due to a lack of targeting. pHILIP® peptide targets cytotoxic compounds to acidic diseased tissue, translocates cytotoxic compounds across plasma membranes into the cytosols of cells in acidic diseased tissues and induces cell death predominantly in the targeted acidic diseased tissue.
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公开(公告)号：US20240173258A1
公开(公告)日：2024-05-30
申请号：US18499655
申请日：2023-11-01
IPC分类号： A61K9/127 , A61K31/20 , A61K31/337 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K47/69 , A61P35/00
CPC分类号： A61K9/1271 , A61K9/127 , A61K31/20 , A61K31/337 , A61K31/704 , A61K31/7105 , A61K31/711 , A61K31/713 , A61K47/6911 , A61P35/00
摘要： The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide.
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3.发明公开公开(公告)号：US20240075170A1
公开(公告)日：2024-03-07
申请号：US18349855
申请日：2023-07-10
IPC分类号： A61K49/00 , A61B5/00 , A61K49/04 , A61K49/22 , C07K14/00 , C07K19/00 , C09B69/10 , C09K11/06 , G01N33/58
CPC分类号： A61K49/0056 , A61B5/0082 , A61K49/0034 , A61K49/04 , A61K49/221 , A61K49/227 , C07K14/001 , C07K19/00 , C09B69/107 , C09K11/06 , G01N33/582 , A61B5/0071 , C09K2211/1466
摘要： The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
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4.发明公开公开(公告)号：US20240148911A1
公开(公告)日：2024-05-09
申请号：US18349851
申请日：2023-07-10
IPC分类号： A61K49/00 , A61B5/00 , A61K49/04 , A61K49/22 , C07K14/00 , C07K19/00 , C09B69/10 , C09K11/06 , G01N33/58
CPC分类号： A61K49/0056 , A61B5/0082 , A61K49/0034 , A61K49/04 , A61K49/221 , A61K49/227 , C07K14/001 , C07K19/00 , C09B69/107 , C09K11/06 , G01N33/582 , A61B5/0071 , C09K2211/1466
摘要： The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
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公开(公告)号：US20240066096A1
公开(公告)日：2024-02-29
申请号：US18325884
申请日：2023-05-30
CPC分类号： A61K38/16 , A61K38/195 , A61K38/20 , A61K47/00 , A61K2121/00 , C07K2319/33
摘要： The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIP● construct comprising an antibody recruiting molecule linked to one or more pHLIP● peptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.
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公开(公告)号：US20240042063A1
公开(公告)日：2024-02-08
申请号：US18331904
申请日：2023-06-08
CPC分类号： A61K49/0056 , G01N33/84 , C07K7/06 , A61K47/65 , A61K47/42 , A61B5/0071 , A61K47/64 , C07K14/00 , G01N2033/0003
摘要： Provided herein are, inter alia, pH-triggered compounds and compositions comprising one or more peptides that are capable of inserting into a lipid bilayer below a certain pH. Treatment, imaging, diagnostic, and other uses of such compounds and compositions are also provided.
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公开(公告)号：US20230372551A1
公开(公告)日：2023-11-23
申请号：US18027337
申请日：2021-09-21
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES , SLOAN-KETTERING INSTITUTE OF CANCER RESEARCH , UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES , PHLIP, INC.
CPC分类号： A61K51/088 , C07K14/001 , A61K2123/00
摘要： The present disclosure provides compounds, complexes, compositions, and methods for the detection of cancer. Specifically, the compounds, complexes, compositions of the present technology include pH (low) insertion peptides. Also disclosed herein are methods of using the complexes and compositions of the present technology in diagnostic imaging to detect cancer in a subject.
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公开(公告)号：US20240156998A1
公开(公告)日：2024-05-16
申请号：US18353822
申请日：2023-07-17
申请人： MEMORIAL SLOAN KETTERING CANCER CENTER , UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES , PHLIP, INC.
CPC分类号： A61K51/088 , A61K47/545 , A61K47/547 , A61K47/64 , A61K49/0056 , A61K49/085 , A61K49/124
摘要： The present disclosure provides compounds, complexes, compositions, and methods for the detection of cancer. Specifically, the compounds, complexes, compositions of the present technology include pH (low) insertion peptides. Also disclosed herein are methods of using the complexes and compositions of the present technology in diagnostic imaging to detect cancer in a subject.
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