- 专利标题： RECOMBINANT BACTERIA ENGINEERED TO TREAT DISEASES ASSOCIATED WITH METHIONINE METABOLISM AND METHODS OF USE THEREOF
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申请号： US18524651申请日： 2023-11-30
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公开(公告)号： US20240102024A1公开(公告)日： 2024-03-28
- 发明人: Dylan Alexander Carlin , Vincent M. Isabella , Jonathan McMurry , Theodore Carlton Moore, III , Mylene Perreault , Nathan Schmidt , Mark Simon
- 申请人： Synlogic Operating Company, Inc. , Ginkgo Bioworks, Inc.
- 申请人地址： US MA Cambridge
- 专利权人： Synlogic Operating Company, Inc.,Ginkgo Bioworks, Inc.
- 当前专利权人： Synlogic Operating Company, Inc.,Ginkgo Bioworks, Inc.
- 当前专利权人地址： US MA Cambridge
- 主分类号： C12N15/52
- IPC分类号： C12N15/52 ; A61K35/741 ; C07K14/245 ; C12N9/88 ; C12N15/70
摘要：
The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.
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