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公开(公告)号：US20240261438A1
公开(公告)日：2024-08-08
申请号：US18435561
申请日：2024-02-07
发明人： Kevin Sheets , Erin Borchardt
CPC分类号： A61K48/0058 , A61K38/53 , A61P25/28 , C12N7/00 , C12N15/86 , C12Y603/02019 , C12N2750/14143 , C12N2750/14151
摘要： The disclosure provides nucleic acids (comprising AAV expression cassettes), AAV vectors, and compositions for use in methods for treating and/or delaying the onset of diseases associated with mutations in genes, such as UBE3A, associated with Angelman syndrome. Also, provided herein are methods for treating and/or delaying the onset of Angelman syndrome.
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公开(公告)号：US20240200019A1
公开(公告)日：2024-06-20
申请号：US18288954
申请日：2022-04-28
IPC分类号： C12N1/16 , C12N9/10 , C12N9/88 , C12N15/81 , C12P5/00 , C12P7/6454 , C12P7/6463 , C12R1/645
CPC分类号： C12N1/165 , C12N9/1029 , C12N9/88 , C12N15/815 , C12P5/007 , C12P7/6454 , C12P7/6463 , C07K2319/00 , C12R2001/645 , C12Y203/01008 , C12Y401/02009
摘要： Aspects of the disclosure are directed to genetically modified yeast cells and methods for use. Certain aspects are directed to recombinant yeast cells comprising exogenous nucleic acid sequences encoding phosphotransacetylase and/or phosphoketolase proteins, including a phosphoketolase protein from Clostridium acetobutylicum. Also disclosed are methods for generating recombinant yeast cells and methods of use of such cells for production of one or more products, including lipids, oils, fatty acids, and triacylglycerides.
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公开(公告)号：US11981914B2
公开(公告)日：2024-05-14
申请号：US18372334
申请日：2023-09-25
发明人： Daniel McCoy , Garrett E. Berry
IPC分类号： C12N15/864 , A61K48/00 , C07K14/005 , C12N7/00 , C12N9/22 , C12N15/11 , C12N15/86
CPC分类号： C12N15/86 , C07K14/005 , A61K48/00 , C12N2750/14122 , C12N2750/14143
摘要： AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein are described. Also described are methods of administering the virus vectors and virus capsids to a cell or to a subject in vivo.
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公开(公告)号：US20240084340A1
公开(公告)日：2024-03-14
申请号：US18227147
申请日：2023-07-27
CPC分类号： C12P7/6409 , A23D9/02 , C11B1/10 , C11C3/00 , C12N9/001 , C12N9/1007 , C12Q1/686
摘要： Nucleic acids and cells comprising a methyltransferase gene and/or a reductase gene are disclosed. These nucleic acids and cells may be used to produce branched (methyl)lipids, such as 10-methylstearate.
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公开(公告)号：US20240026392A1
公开(公告)日：2024-01-25
申请号：US18015046
申请日：2021-07-08
发明人： Kim Cecelia Anderson , Jeffrey Ian Boucher , Elena Brevnova , Brian Carvalho , Nicholas Flores , Katrina Forrest , Fiona Qu , Gabriel Rodrigues , Michelle Spencer
CPC分类号： C12P7/42 , C12P7/22 , C12N15/81 , C12Y121/03008 , C12Y404/01026 , C12Y205/0101 , C12Y203/01206 , C12N2800/102
摘要： Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro, and to variant terminal synthases having altered catalytic activity to synthesize THC-type, CBD-type and/or CBC-type cannabinoids.
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公开(公告)号：US20240002847A1
公开(公告)日：2024-01-04
申请号：US18037215
申请日：2021-11-12
IPC分类号： C12N15/113 , C12P21/02
CPC分类号： C12N15/113 , C12P21/02
摘要： This application describes synthetic promoters capable of facilitating the high-yield synthesis of proteins and molecules.
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公开(公告)号：US11697829B2
公开(公告)日：2023-07-11
申请号：US16943819
申请日：2020-07-30
CPC分类号： C12P7/40 , C12N9/0006 , C12N9/0051 , C12N15/52 , C12N15/70 , C12P5/00 , C12P7/00 , C12P7/16 , C12Y101/05006 , C12Y108/05004 , Y02E50/10
摘要： The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
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公开(公告)号：US11572546B2
公开(公告)日：2023-02-07
申请号：US16942509
申请日：2020-07-29
摘要： The current methods and compositions provide for nucleotide sequences of promoters from Yarrowia lipolytica which may be used to drive gene expression in a cell. In some aspects, the promoters are useful for modulating lipid production in oleaginous organisms such as yeast.
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公开(公告)号：US20220348889A1
公开(公告)日：2022-11-03
申请号：US17744578
申请日：2022-05-13
IPC分类号： C12N9/02
摘要： The present invention relates to methods and compositions that include enzymes and/or binding polypeptides useful for protecting polymers from damage caused by fatty acids from secreted biological fluids such as sebum or sweat.
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公开(公告)号：US20220307060A1
公开(公告)日：2022-09-29
申请号：US17690446
申请日：2022-03-09
发明人： Kim Cecelia Anderson , Elena Brevnova , Dylan Alexander Carlin , Brian Carvalho , Nicholas Flores , Katrina Forrest , Matthew McMahon , Massimo Merighi , Gabriel Rodriguez , Emily E. Wrenbeck
摘要： Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
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