Methods and apparatus for targeted wake-up and frame enhancement for energy harvesting are disclosed. In one embodiment, a method performed by a station (STA) may compromise: receiving, during an energy detection state, a zero energy (ZE) frame from an access point (AP) that indicates a presence of an energy harvesting (EH) window; harvesting energy for a determined time duration during the EH window; and receiving, during an information decoding state, a data portion of the ZE frame based on a current stored energy of the STA being above a first threshold and a signal strength of the received ZE frame being above a second threshold.