Invention Publication
- Patent Title: PYRIDO OXAZINE DERIVATIVES AS ALK5 INHIBITORS
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Application No.: US18269042Application Date: 2021-12-20
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Publication No.: US20240116948A1Publication Date: 2024-04-11
- Inventor: Daniele PALA , Daniela PIZZIRANI , Paolo BRUNO , Matteo BIAGETTI , Paolo RONCHI , Sara GUARIENTO , Barbara BERTANI , Donatella RESCIGNO
- Applicant: CHIESI FARMACEUTICI S.P.A.
- Applicant Address: IT Parma
- Assignee: CHIESI FARMACEUTICI S.P.A.
- Current Assignee: CHIESI FARMACEUTICI S.P.A.
- Current Assignee Address: IT Parma
- Priority: EP 217161.7 2020.12.23
- International Application: PCT/EP2021/086707 2021.12.20
- Date entered country: 2023-06-22
- Main IPC: C07D498/04
- IPC: C07D498/04 ; C07D519/00
Abstract:
The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-β (TGF-β) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.
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