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公开(公告)号：US20240025880A1
公开(公告)日：2024-01-25
申请号：US18038744
申请日：2021-11-26
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Claudio FIORELLI , Paolo BRUNO , Matteo BIAGETTI , Daniela PIZZIRANI , Daniele PALA , Paolo RONCHI , Sara GUARIENTO , Charles BAKER-GLENN , Hervé VAN DE POËL , Kim Louise HIRST
IPC: C07D403/12 , C07D401/14 , C07D419/00 , C07D403/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D405/14
CPC classification number: C07D403/12 , C07D401/14 , C07D419/00 , C07D403/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D405/14
Abstract: The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
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公开(公告)号：US20220227749A1
公开(公告)日：2022-07-21
申请号：US17615017
申请日：2020-05-28
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Paolo BRUNO , Matteo BIAGETTI , Claudio FIORELLI , Daniela PIZZIRANI , Daniele PALA , Paolo RONCHI , Charles BAKER-GLENN , Hervè VAN DE POËL , Kim Louise HIRST , Sara GUARIENTO
IPC: C07D417/12 , C07D405/14 , C07F5/02 , C07D417/14 , C07D403/14 , C07D403/12 , C07D413/12 , C07D401/12
Abstract: The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
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公开(公告)号：US20240190891A1
公开(公告)日：2024-06-13
申请号：US18014770
申请日：2021-07-14
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Daniele PALA , Daniela PIZZIRANI , Paolo BRUNO , Matteo BIAGETTI , Paolo RONCHI , Sara GUARIENTO , Claudio FIORELLI , Barbara BERTANI
IPC: C07D498/04 , A61K31/5383 , C07D519/00
CPC classification number: C07D498/04 , A61K31/5383 , C07D519/00
Abstract: The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-β (TGF-β) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.
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公开(公告)号：US20240018122A1
公开(公告)日：2024-01-18
申请号：US18014764
申请日：2021-07-14
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Daniela PIZZIRANI , Matteo BIAGETTI , Paolo RONCHI , Paolo BRUNO , Sara GUARIENTO , Barbara BERTANI , Daniele PALA , Alessio BARILLI
IPC: C07D401/14 , C07D401/12 , C07D405/14 , C07D471/04 , C07D487/04
CPC classification number: C07D401/14 , C07D401/12 , C07D487/04 , C07D471/04 , C07D405/14
Abstract: The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-β (TGF-β) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.
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公开(公告)号：US20250100997A1
公开(公告)日：2025-03-27
申请号：US18728106
申请日：2023-01-10
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Daniela PIZZIRANI , Paolo RONCHI , Donatella RESCIGNO
IPC: C07D401/14 , A61K31/501 , C07D405/14 , C07D409/14 , C07D413/14
Abstract: The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-β (TGF-β) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.
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Patent Agency Ranking
公开(公告)号：US20240116947A1
公开(公告)日：2024-04-11
申请号：US18014775
申请日：2021-07-14
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Daniele PALA , Daniela PIZZIRANI , Paolo BRUNO , Paolo RONCHI , Matteo BIAGETTI , Sara GUARIENTO , Claudio FIORELLI
IPC: C07D498/04 , C07D519/00
CPC classification number: C07D498/04 , C07D519/00
Abstract: The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-β (TGF-β) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.
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公开(公告)号：US20250011299A1
公开(公告)日：2025-01-09
申请号：US18693564
申请日：2022-09-20
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Daniela PIZZIRANI , Paolo RONCHI , Sara GUARIENTO , Daniele PALA , Paolo BRUNO , Teresa SEMERARO , Donatella RESCIGNO
IPC: C07D401/12 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D471/04 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/18 , C07D491/107
Abstract: The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-β (TGF-β) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.
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公开(公告)号：US20240116948A1
公开(公告)日：2024-04-11
申请号：US18269042
申请日：2021-12-20
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Daniele PALA , Daniela PIZZIRANI , Paolo BRUNO , Matteo BIAGETTI , Paolo RONCHI , Sara GUARIENTO , Barbara BERTANI , Donatella RESCIGNO
IPC: C07D498/04 , C07D519/00
CPC classification number: C07D498/04 , C07D519/00
Abstract: The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-β (TGF-β) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.
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公开(公告)号：US20230092892A1
公开(公告)日：2023-03-23
申请号：US17615056
申请日：2020-05-28
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Paolo BRUNO , Matteo BIAGETTI , Claudio FIORELLI , Daniela PIZZIRANI , Daniele PALA , Paolo RONCHI , Charles BAKER-GLENN , Hervè VAN DE POËL , Kim Louise HIRST
IPC: C07D403/12 , C07D401/12 , C07D487/04 , C07D417/14 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/12 , C07D413/12 , C07D239/94 , C07D409/14 , C07D409/12
Abstract: The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
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公开(公告)号：US20220175784A1
公开(公告)日：2022-06-09
申请号：US17600676
申请日：2020-03-24
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Matteo BIAGETTI , Paolo RONCHI , Claudio FIORELLI , Paolo BRUNO
IPC: A61K31/519 , A61K9/00 , C07D487/04
Abstract: The invention relates to compounds of formula (I) inhibiting phosphoinositide 3-kinases (PI3K), to pharmaceutical compositions comprising them and therapeutic use thereof in the treatment of disorders associated with PI3K enzymes.
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