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公开(公告)号：US20240116947A1
公开(公告)日：2024-04-11
申请号：US18014775
申请日：2021-07-14
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Daniele PALA , Daniela PIZZIRANI , Paolo BRUNO , Paolo RONCHI , Matteo BIAGETTI , Sara GUARIENTO , Claudio FIORELLI
IPC: C07D498/04 , C07D519/00
CPC classification number: C07D498/04 , C07D519/00
Abstract: The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-β (TGF-β) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.
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公开(公告)号：US20240190891A1
公开(公告)日：2024-06-13
申请号：US18014770
申请日：2021-07-14
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Daniele PALA , Daniela PIZZIRANI , Paolo BRUNO , Matteo BIAGETTI , Paolo RONCHI , Sara GUARIENTO , Claudio FIORELLI , Barbara BERTANI
IPC: C07D498/04 , A61K31/5383 , C07D519/00
CPC classification number: C07D498/04 , A61K31/5383 , C07D519/00
Abstract: The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-β (TGF-β) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.
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公开(公告)号：US20240018122A1
公开(公告)日：2024-01-18
申请号：US18014764
申请日：2021-07-14
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Daniela PIZZIRANI , Matteo BIAGETTI , Paolo RONCHI , Paolo BRUNO , Sara GUARIENTO , Barbara BERTANI , Daniele PALA , Alessio BARILLI
IPC: C07D401/14 , C07D401/12 , C07D405/14 , C07D471/04 , C07D487/04
CPC classification number: C07D401/14 , C07D401/12 , C07D487/04 , C07D471/04 , C07D405/14
Abstract: The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-β (TGF-β) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.
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公开(公告)号：US20220235060A1
公开(公告)日：2022-07-28
申请号：US17615012
申请日：2020-05-28
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Paolo BRUNO , Matteo BIAGETTI , Claudio FIORELLI , Charles BAKER-GLENN , Hervè VAN DE POËL , Stephen David PENROSE , Roberta LANARO
IPC: C07D487/04 , C07D471/04
Abstract: The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3 (hereinafter P2X3 inhibitors); particularly the invention relates to compounds that are pyridopyrimidines derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
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公开(公告)号：US20150361100A1
公开(公告)日：2015-12-17
申请号：US14741965
申请日：2015-06-17
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Matteo BIAGETTI , Alessandro ACCETTA , Anna Maria CAPELLI , Matilde GUALA , Michele RETINI
IPC: C07D519/00 , C07D471/04 , A61K31/519 , A61K31/497 , A61K31/5377 , A61K31/52 , A61K31/506
CPC classification number: C07D519/00 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , C07D471/04 , C07D473/02 , C07D487/04 , Y02A50/409
Abstract: Compounds of formula (I), defined herein, inhibit phosphoinositide 3-kinases (PI3K) and are useful for the treatment of disorders associated with PI3K enzymes.
Abstract translation: 本文定义的式（I）化合物抑制磷酸肌醇3-激酶（PI3K），可用于治疗与PI3K酶相关的疾病。
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Patent Agency Ranking
公开(公告)号：US20240025880A1
公开(公告)日：2024-01-25
申请号：US18038744
申请日：2021-11-26
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Claudio FIORELLI , Paolo BRUNO , Matteo BIAGETTI , Daniela PIZZIRANI , Daniele PALA , Paolo RONCHI , Sara GUARIENTO , Charles BAKER-GLENN , Hervé VAN DE POËL , Kim Louise HIRST
IPC: C07D403/12 , C07D401/14 , C07D419/00 , C07D403/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D405/14
CPC classification number: C07D403/12 , C07D401/14 , C07D419/00 , C07D403/14 , C07D417/12 , C07D413/14 , C07D413/12 , C07D405/14
Abstract: The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are amino quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
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公开(公告)号：US20230212169A9
公开(公告)日：2023-07-06
申请号：US17615012
申请日：2020-05-28
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Paolo BRUNO , Matteo BIAGETTI , Claudio FIORELLI , Charles BAKER-GLENN , Hervè VAN DE POËL , Stephen David PENROSE , Roberta LANARO
IPC: C07D487/04 , C07D471/04
CPC classification number: C07D487/04 , C07D471/04
Abstract: The present invention relates to compounds of formula I inhibiting P2X purinoceptor 3 (hereinafter P2X3 inhibitors); particularly the invention relates to compounds that are pyridopyrimidines derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
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公开(公告)号：US20160303123A1
公开(公告)日：2016-10-20
申请号：US15079740
申请日：2016-03-24
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Anna Maria CAPELLI , Matteo BIAGETTI , Alessandro ACCETTA
IPC: A61K31/506 , A61K31/519 , A61K31/52 , C07D487/04 , C07D405/12 , C07D473/34
CPC classification number: A61K31/506 , A61K31/519 , A61K31/52 , C07D403/12 , C07D405/12 , C07D473/34 , C07D487/04
Abstract: Chromene compounds of formula (I), defined herein, inhibit phosphoinositide 3-kinases (PI3K) and are useful for the treatment of disorders associated with a PI3K enzyme mechanism, such as asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis.
Abstract translation: 本文定义的式（I）的色烯化合物抑制磷酸肌醇3-激酶（PI3K），并且可用于治疗与PI3K酶机制相关的疾病，例如哮喘，慢性阻塞性肺病和特发性肺纤维化。
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公开(公告)号：US20160075710A1
公开(公告)日：2016-03-17
申请号：US14840420
申请日：2015-08-31
Applicant: CHIESI FARMACEUTICI S.p.A.
Inventor： Matteo BIAGETTI , Anna Maria Capelli , Matilde Guala
IPC: C07D487/04 , A61K31/5377 , A61K31/52 , A61K31/506 , C07D473/34 , A61K31/519 , C07D403/12
CPC classification number: C07D487/04 , A61K31/506 , A61K31/519 , A61K31/52 , A61K31/5377 , C07D403/12 , C07D473/34 , Y02A50/409
Abstract: Compounds of formula (I) described herein inhibit phosphoinositide 3-kinases (PI3K) and useful for the treatment of disorders associated with PI3K enzymes.
Abstract translation: 本文所述的式（I）化合物抑制磷酸肌醇3-激酶（PI3K）并且可用于治疗与PI3K酶相关的病症。
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公开(公告)号：US20240002371A1
公开(公告)日：2024-01-04
申请号：US18038802
申请日：2021-11-26
Applicant: CHIESI FARMACEUTICI S.P.A.
Inventor： Claudio FIORELLI , Paolo BRUNO , Matteo BIAGETTI , Charles BAKER-GLENN , Hervè VAN DE POËL
IPC: C07D405/14 , C07D237/34 , C07D403/12 , C07D417/14
CPC classification number: C07D405/14 , C07D237/34 , C07D403/12 , C07D417/14
Abstract: The present invention relates to compounds of formula (I) inhibiting P2X purinoceptor 3; particularly the invention relates to compounds that are phthalazine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of many disorders associated with P2X3 receptors mechanisms, such as respiratory diseases including cough, asthma, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD).
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