- 专利标题： MRNAS ENCODING GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR FOR TREATING PARKINSON'S DISEASE
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申请号： US17768514申请日： 2020-10-15
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公开(公告)号： US20240123034A1公开(公告)日： 2024-04-18
- 发明人: Eric Yi-Chun Huang , Jared Iacovelli , Seymour De Picciotto , Sze-Wah Tse , Laurie Kenney , Katherine Olson , Howard Gendelman , Lee R. Mosley
- 申请人： ModernaTX, Inc. , BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
- 申请人地址： US MA Cambridge
- 专利权人： ModernaTX, Inc.,BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
- 当前专利权人： ModernaTX, Inc.,BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
- 当前专利权人地址： US MA Cambridge
- 国际申请： PCT/US20/55852 2020.10.15
- 进入国家日期： 2022-04-13
- 主分类号： A61K38/19
- IPC分类号： A61K38/19 ; A61K9/51 ; A61K31/7115 ; A61P25/16
摘要：
The disclosure features lipid nanoparticle (LNP) compositions comprising mRNA molecules encoding human granulocyte macrophage colony stimulating factor (GM-CSF) polypeptides and uses thereof in the treatment of Parkinson's Disease. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding human GM-CSF for use in such treatment.
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