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1.发明公开公开(公告)号：US20240123034A1
公开(公告)日：2024-04-18
申请号：US17768514
申请日：2020-10-15
发明人： Eric Yi-Chun Huang , Jared Iacovelli , Seymour De Picciotto , Sze-Wah Tse , Laurie Kenney , Katherine Olson , Howard Gendelman , Lee R. Mosley
IPC分类号： A61K38/19 , A61K9/51 , A61K31/7115 , A61P25/16
CPC分类号： A61K38/193 , A61K9/5123 , A61K31/7115 , A61P25/16
摘要： The disclosure features lipid nanoparticle (LNP) compositions comprising mRNA molecules encoding human granulocyte macrophage colony stimulating factor (GM-CSF) polypeptides and uses thereof in the treatment of Parkinson's Disease. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding human GM-CSF for use in such treatment.
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公开(公告)号：US20210220467A1
公开(公告)日：2021-07-22
申请号：US17204801
申请日：2021-03-17
申请人： ModernaTX, Inc.
IPC分类号： A61K39/145 , A61K48/00 , A61K31/7105 , A61K39/12 , A61K39/39 , A61K9/00 , A61K39/155 , A61K9/127 , A61K9/51 , C12N7/00
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.
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3.发明授权公开(公告)号：US10881730B2
公开(公告)日：2021-01-05
申请号：US16279372
申请日：2019-02-19
申请人： ModernaTX, Inc.
摘要： The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator. The disclosure also features methods of using the same, for example, to stimulate anti-cancer immune responses.
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公开(公告)号：US10517940B2
公开(公告)日：2019-12-31
申请号：US16136386
申请日：2018-09-20
申请人： ModernaTX, Inc.
IPC分类号： A61K39/12 , A61K9/00 , A61K9/127 , A61K9/51 , A61K39/39 , A61K48/00 , A61K39/42 , A61K39/015 , A61K39/00
摘要： The disclosure relates to Zika virus infection and the treatment thereof. The invention includes ribonucleic acid compositions, as well as methods of using the compositions for treating and preventing Zika virus infection.
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公开(公告)号：US20190192653A1
公开(公告)日：2019-06-27
申请号：US16053839
申请日：2018-08-03
申请人： ModernaTX, Inc.
CPC分类号： A61K39/39 , A61K39/00 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/38 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/572 , C12N15/88
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of molecules for tolerizing cellular systems.
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公开(公告)号：US20190015501A1
公开(公告)日：2019-01-17
申请号：US16144394
申请日：2018-09-27
申请人： ModernaTX, Inc.
IPC分类号： A61K39/145 , A61K48/00 , A61K9/127 , A61K9/51 , A61K31/7105 , A61K39/12 , C12N7/00 , A61K9/00 , A61K39/39 , A61K39/155 , A61K39/00
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.
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公开(公告)号：US20190000959A1
公开(公告)日：2019-01-03
申请号：US16048154
申请日：2018-07-27
申请人： ModernaTX, Inc.
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.
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公开(公告)号：US20180318409A1
公开(公告)日：2018-11-08
申请号：US15769710
申请日：2016-10-21
申请人： ModernaTX, Inc.
CPC分类号： A61K39/001114 , A61K9/10 , A61K9/5123 , A61K39/0011 , A61K2039/53 , A61K2039/545 , A61K2039/55588 , A61P35/00
摘要： The disclosure relates to cancer ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.
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公开(公告)号：US20230130155A1
公开(公告)日：2023-04-27
申请号：US17759687
申请日：2021-01-29
申请人： ModernaTX, Inc.
IPC分类号： A61K9/51 , A61K31/7105 , B82Y5/00 , A61P37/06
摘要： The disclosure features lipid nanoparticle (LNP) compositions comprising metabolic reprogramming molecules and uses thereof. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding metabolic reprogramming polypeptides, e.g., IDO, TDO, AMPK, AhR, ALDH1A2, HMOX1, CD73 or CD39. The LNP compositions of the present disclosure can reprogram myeloid and/or dendritic cells, suppress T cells and/or induce immune tolerance in vivo.
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公开(公告)号：US11576961B2
公开(公告)日：2023-02-14
申请号：US16493986
申请日：2018-03-15
申请人： ModernaTX, Inc.
发明人： Giuseppe Ciaramella , Eric Yi-Chun Huang , Kerim Babaoglu , Jessica Anne Flynn , Lan Zhang , David Nickle
IPC分类号： A61K39/145 , A61K39/00
摘要： The disclosure relates to broad spectrum influenza virus ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccine. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.
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