Invention Publication
- Patent Title: Post-Natal Transplantation Of Factor VIII-Expressing Cells For Treatment of Hemophilia
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Application No.: US18129398Application Date: 2023-03-31
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Publication No.: US20240139253A1Publication Date: 2024-05-02
- Inventor: Maria Graca N.D. Almeida-Porada , Christopher D. Porada , Anthony Atala , Christopher B. Doering , H. Trent Spencer
- Applicant: Wake Forest University Health Sciences , Emory University , Children's Healthcare of Atlanta, Inc.
- Applicant Address: US NC Winston-Salem
- Assignee: Wake Forest University Health Sciences,Emory University,Children's Healthcare of Atlanta, Inc.
- Current Assignee: Wake Forest University Health Sciences,Emory University,Children's Healthcare of Atlanta, Inc.
- Current Assignee Address: US NC Winston-Salem
- Main IPC: A61K35/28
- IPC: A61K35/28 ; A61K38/37 ; C12N5/0775
Abstract:
Disclosed herein are method of treating hemophilia A in a subject comprising injecting the subject with mesenchymal stromal/stem cells (MSC) modified to express high levels of Factor VIII protein. The MSC are isolated prenatally, at birth, or after the subject's birth. The modified MSC may also express high levels von Willebrand factor protein.
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