The technology involves transistor-level synthesis for integrated circuit design and fabrication. According to one aspect, a computer-implemented method performs transistor-level synthesis for an integrated circuit element. This includes generating single-stage transistor networks from Boolean functions, in which each single-stage transistor network is composed of a pulldown network and a pullup network. The single-stage transistor networks are scaled to multi-stage transistor networks to globally optimize for factored form literals. Technology mapping can then be performed based on the factored form literals to generate a circuit design.