Example channel circuits, data storage devices, and methods for using a trained neural network to estimate the noise mixture in a read signal are described. Samples are determined from a digital read signal, such as the read signal from the non-volatile storage medium of a data storage device. The samples are processed through one or more instances of a neural network comprised of trained coefficients and outputting a set of estimate values for a noise mixture of the read signal. The set of estimate values may then be used to adjust parameters of the read channel for processing the read signal to detect and decode data.