A locator device and system with an expandable element facilitating imaging of the locator device at a target site at a first anatomical location within a patient from a remote second anatomical location within the patient. The locator device may be formed of a material capable of being imaged from the remote second anatomical location. The locator device may be expandable to contact the interior of the anatomical structure at the first anatomical location to facilitate deployment and to resist movement with respect thereto. The locator device may be separable from the delivery system used to deliver the locator device and left in place at the target site. The locator device may expand the anatomical structure at the first anatomical location to facilitate imaging of such structure from the remote second anatomical structure. In some instances, the locator device may be returned to the delivery configuration and removed from the target site.