Invention Publication
- Patent Title: Quantum Dot-Nucleotide Based Ratiometric Fluorescent Molecular Beacon for Quantitative CRISPR/Cas Activity Detection
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Application No.: US18346973Application Date: 2023-07-05
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Publication No.: US20240175076A1Publication Date: 2024-05-30
- Inventor: Sebastián A. Díaz , Christopher M. Green , Joseph R. Spangler , Divita Mathur , Kimihiro Susumu , David A. Stenger , Igor L. Medintz
- Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
- Applicant Address: US VA Arlington
- Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
- Current Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
- Current Assignee Address: US VA Arlington
- Main IPC: C12Q1/6818
- IPC: C12Q1/6818 ; C12Q1/6876 ; C12Q1/6806
Abstract:
A flexible strategy for assembling luminescent and colorimetric quantum dot/nucleic acid hairpin (QD-HP) molecular beacons for use in CRISPR/Cas diagnostics uses chimeric peptide/peptide nucleic acid (PNA) to conjugate fluorescently labeled DNA or RNA hairpins to ZnS-coated QDs.
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