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公开(公告)号：US12116519B2
公开(公告)日：2024-10-15
申请号：US17713983
申请日：2022-04-05
IPC分类号： C09K11/02 , C07C323/60 , C07D339/04 , C08F138/00 , C09K11/06 , C09K11/08 , C09K11/88
CPC分类号： C09K11/886 , C07C323/60 , C07D339/04 , C08F138/00 , C09K11/02
摘要： This disclosure concerns a method of making a ligand for Quantum Dot functionalization, a method of making a functionalized Quantum Dot (QD) with a ligand, and a method of making a transparent luminescent quantum dot thiol-yne nanocomposite with tailorable optical, thermal, and mechanical properties. The prepolymer solution and functionalized Quantum Dot can be used in additive manufacturing.
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2.发明公开公开(公告)号：US20230373003A1
公开(公告)日：2023-11-23
申请号：US18197195
申请日：2023-05-15
发明人： Eunkeu Oh , Kimihiro Susumu , Ajmeeta Sangtani , Katherine Rogers , Okhil K. Nag , Kwahun Lee , Igor Vurgaftman , R. Joseph Weiblen , Mijin Kim , James B. Delehanty
CPC分类号： B22F9/24 , B22F1/056 , B22F1/0553 , B22F2998/10 , B22F2301/255 , B22F2009/245 , B22F2304/054 , B22F2304/058 , B22F2304/056
摘要： A new seedless synthesis of anisotropic nanoscale gold nanoflower (AuNF) particles uses bidentate thiolate ligands to protect the nanoparticle surface and a combination of reagents (for example, ligand, ascorbic acid, and hydroxide) to synthesis AuNF with controlled size and anisotropic properties. Compared to prior art gold nanospheres, AuNF produced approximately a 15-fold improvement in a drug delivery assay.
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公开(公告)号：US20240254531A1
公开(公告)日：2024-08-01
申请号：US18425004
申请日：2024-01-29
发明人： Joyce C. Breger , Kimihiro Susumu , Igor L. Medintz , Gregory A. Ellis , Sebastian A. Diaz , Shelby L. Hooe
CPC分类号： C12P19/32 , C12N9/0008 , C12N9/1217 , C12N9/88 , C12Y102/01011 , C12Y207/02004 , C12Y403/01001
摘要： Enzyme cascade reactions, wherein the product of a first enzyme is the substrate of a second enzyme and so forth, were found to be enhanced by the presence of peptides. It is believed that the peptides operate by forming coacervates, which are membrane-less compartments where, in the case of coacervates formed by peptides, the liquid-liquid phase separation involves water as the continuous phase both inside and outside the coacervate.
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公开(公告)号：US11512305B2
公开(公告)日：2022-11-29
申请号：US15840283
申请日：2017-12-13
摘要： A nanoparticle (for example, quantum dot) serves as a substrate for immobilizing enzymes involved in consecutive reactions as a cascade. This results in a significant increase in the rate of catalysis as well as final product yield compared to non-immobilized enzymes.
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公开(公告)号：US20220228061A1
公开(公告)日：2022-07-21
申请号：US17713983
申请日：2022-04-05
IPC分类号： C09K11/88 , C09K11/02 , C07D339/04
摘要： This disclosure concerns a method of making a ligand for Quantum Dot functionalization, a method of making a functionalized Quantum Dot (QD) with a ligand, and a method of making a transparent luminescent quantum dot thiol-yne nanocomposite with tailorable optical, thermal, and mechanical properties. The prepolymer solution and functionalized Quantum Dot can be used in additive manufacturing.
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6.发明公开公开(公告)号：US20230250126A1
公开(公告)日：2023-08-10
申请号：US18160925
申请日：2023-01-27
发明人： Igor L. Medintz , Joseph Melinger , William B. Knowlton , Bernard Yurke , Kimihiro Susumu , Sang Ho Lee , Adam Meares , Divita Mathur , Olga A. Mass , Jeunghoon Lee , Ryan D. Pensack
IPC分类号： C07H21/00
CPC分类号： C07H21/00
摘要： New phosphoramidite Cy5 derivatives can be used in automated DNA synthesis, allowing the labeling of DNA sequences with a wider array of chromophores than are presently commercially available. In addition to varying dye hydrophobicity/hydrophilicity, the 5,5′-substituents (including hexyloxy, triethyleneglycol monomethyl ether, tert-butyl, and chloro groups) can modulate electron donating/withdrawing character while also tuning resulting absorption and emission properties. Modification of the Cy5 periphery enables the tuning of photophysical properties, such as absorption and emission maxima, fluorescence quantum yield, and fluorescence lifetime.
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公开(公告)号：US10705092B2
公开(公告)日：2020-07-07
申请号：US15882259
申请日：2018-01-29
发明人： James B. Delehanty , Michael H. Stewart , Okhil Nag , Jeffrey R. Deschamps , Kimihiro Susumu , Eunkeu Oh , Lauren D. Field , Alexander L. Efros , Alan L. Huston , Igor L. Medintz , Philip E. Dawson
IPC分类号： G01N33/58
摘要： A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Emission correlates with cellular membrane potential.
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8.发明申请公开(公告)号：US20180326097A1
公开(公告)日：2018-11-15
申请号：US16031094
申请日：2018-07-10
发明人： James B. Delehanty , Michael H. Stewart , Okhil Nag , Jeffrey R. Deschamps , Kimihiro Susumu , Eunkeu Oh , Lauren D. Field , Alexander L. Efros , Alan L. Huston , Igor L. Medintz , Philip E. Dawson , Nashaat Rasheed , Parag V. Chitnis , John R. Cressman
CPC分类号： A61K49/222 , A61K49/221 , G01N33/542 , G01N33/588
摘要： A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor; a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle; and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Photoacoustic emission from the construct correlates with cellular membrane potential.
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公开(公告)号：US20180171325A1
公开(公告)日：2018-06-21
申请号：US15840283
申请日：2017-12-13
摘要： A nanoparticle (for example, quantum dot) serves as a substrate for immobilizing enzymes involved in consecutive reactions as a cascade. This results in a significant increase in the rate of catalysis as well as final product yield compared to non-immobilized enzymes.
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10.发明公开公开(公告)号：US20240344124A1
公开(公告)日：2024-10-17
申请号：US18509355
申请日：2023-11-15
发明人： Christopher M. Green , Joseph R. Spangler , Tomasz A. Leski , Kimihiro Susumu , Sebastian A. Diaz , Igor L. Medintz , David A. Stenger , Scott N. Dean
IPC分类号： C12Q1/6874 , C12Q1/6806
CPC分类号： C12Q1/6874 , C12Q1/6806 , C12Q2600/156
摘要： One can enrich nucleic acid (RNA or DNA) from within a complex mixture in a sequence-specific manner by using a mutant of a Cas enzyme lacking nuclease activity, for example a mutant of Cas13a (dCas) from Leptotrichia wadeii. The nucleic acid is bound by the mutant protein as directed by guide RNA molecules (crRNA) and purified after association with an appropriate surface, such as quantum dots or functionalized beads. The nucleic acid is separated from the Cas and purified after precipitation or interaction with another surface. The resulting product can be directly processed via long-read sequencing.
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