- 专利标题： MACROCYCLES AS CFTR MODULATORS
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申请号： US18550883申请日： 2021-07-12
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公开(公告)号： US20240208992A1公开(公告)日： 2024-06-27
- 发明人: Martin BOLLI , Christine BROTSCHI , Malgorzata COMMANDEUR , John GATFIELD , Thierry KIMMERLIN , Hervé SIENDT , Jasper SPRINGER , Clemens WAGNER , Anita WEGERT , Jodi T. WILLIAMS
- 申请人： Idorsia Pharmaceuticals Ltd
- 申请人地址： CH Allschwil
- 专利权人： Idorsia Pharmaceuticals Ltd
- 当前专利权人： Idorsia Pharmaceuticals Ltd
- 当前专利权人地址： CH Allschwil
- 优先权： WO TEP2021056724 2021.03.16
- 国际申请： PCT/EP2021/069292 2021.07.12
- 进入国家日期： 2023-09-15
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; A61K31/4745
摘要：
The present invention relates to macrocyclic compounds of Formula (I)
wherein Ar1, Ar2, R1, R2, R3, R4, and X are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as modulators of CFTR.
wherein Ar1, Ar2, R1, R2, R3, R4, and X are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as modulators of CFTR.
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