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公开(公告)号：US20210113559A1
公开(公告)日：2021-04-22
申请号：US16614209
申请日：2018-05-17
发明人： Christoph BOSS , Olivier CORMINBOEUF , Heinz FRETZ , Isabelle LYOTHIER , Davide POZZI , Sylvia RICHARD-BILDSTEIN , Hervé SIENDT , Thierry SIFFERLEN
IPC分类号： A61K31/506 , A61K45/06 , C07D409/12 , C07D409/14 , C07D239/26 , A61K31/505 , C07D405/14 , C07D405/12 , C07D413/14 , C07D401/14 , C07D403/12 , C07D401/12 , A61K31/5355 , C07D417/14 , C07D413/12 , A61P35/00
摘要： The present invention relates to pyrimidine derivatives of formula (I) wherein (R1)n, R3, R4a, R4b, R5a, R5b and Ar1 are as described in the description and their use in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor. The invention further relates to novel benzofurane and benzothiophene derivatives of formula (II) and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.
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公开(公告)号：US20210115031A1
公开(公告)日：2021-04-22
申请号：US16614211
申请日：2018-05-17
发明人： Christoph BOSS , Olivier CORMINBOEUF , Heinz FRETZ , Isabelle LYOTHIER , Davide POZZI , Sylvia RICHARD-BILDSTEIN , Hervé SIENDT , Thierry SIFFERLEN
IPC分类号： C07D409/14 , C07D405/12 , C07D413/14
摘要： The present invention relates to benzofurane and benzothiophene derivatives of formula (I) wherein (R1)n, R2, R3, R4a, R4b, R5a, R5b and Ar1 are as described in the description and their use in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor. The invention further relates to novel benzofurane and benzothiophene derivatives of formula (II) and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.
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公开(公告)号：US20200179383A1
公开(公告)日：2020-06-11
申请号：US16614594
申请日：2018-05-17
发明人： Christoph BOSS , Olivier CORMINBOEUF , Heinz FRETZ , Isabelle LYOTHIER , Davide POZZI , Sylvia RICHARD-BILDSTEIN , Hervé SIENDT , Thierry SIFFERLEN
IPC分类号： A61K31/506 , A61P35/04
摘要： The present invention relates to phenyl derivatives of formula (I) wherein (R1)a, R3, R4a, R4b, R5a, R5b and Ar1 are as described in the description and their use in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor. The invention further relates to novel benzofurane and benzothiophene derivatives of formula (III) and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.
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公开(公告)号：US20240208992A1
公开(公告)日：2024-06-27
申请号：US18550883
申请日：2021-07-12
发明人： Martin BOLLI , Christine BROTSCHI , Malgorzata COMMANDEUR , John GATFIELD , Thierry KIMMERLIN , Hervé SIENDT , Jasper SPRINGER , Clemens WAGNER , Anita WEGERT , Jodi T. WILLIAMS
IPC分类号： C07D498/04 , A61K31/4745
CPC分类号： C07D498/04 , A61K31/4745
摘要： The present invention relates to macrocyclic compounds of Formula (I)
wherein Ar1, Ar2, R1, R2, R3, R4, and X are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as modulators of CFTR.
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