公开(公告)号：US20240208992A1

公开(公告)日：2024-06-27

申请号：US18550883

申请日：2021-07-12

申请人： Idorsia Pharmaceuticals Ltd

发明人： Martin BOLLI ,  Christine BROTSCHI ,  Malgorzata COMMANDEUR ,  John GATFIELD ,  Thierry KIMMERLIN ,  Hervé SIENDT ,  Jasper SPRINGER ,  Clemens WAGNER ,  Anita WEGERT ,  Jodi T. WILLIAMS

IPC分类号： C07D498/04 ,  A61K31/4745

CPC分类号： C07D498/04 ,  A61K31/4745

摘要： The present invention relates to macrocyclic compounds of Formula (I)






wherein Ar1, Ar2, R1, R2, R3, R4, and X are as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of Formula (I), and especially to their use as modulators of CFTR.