Embodiments provide systems and methods for a generic representational state transfer (ReST) framework that can be used to communicate with heterogeneous ReST interfaces. On embodiment of a method comprises storing endpoint configurations for heterogeneous ReST interfaces as configurable files consumable by a ReST framework; receiving, by the ReST framework, a request to perform an operation and ReST resource details associated with the request to perform the operation; generating a ReST request, the ReST request including an endpoint URL for a target resource, a Hypertext Transfer Protocol (HTTP) method, and a header; and sending the ReST request to a ReST server. Generating the ReST request can comprise accessing the first endpoint configuration and extract first endpoint configuration data that is applicable to servicing the request to perform the operation, the first endpoint configuration data specifying the header; and mapping the operation to the HTTP method.