- 专利标题： LIPOSOMES DISPLAYING A GLYCAN LIGAND FOR CD33 AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE
-
申请号： US18558999申请日： 2021-05-05
-
公开(公告)号： US20240238442A1公开(公告)日： 2024-07-18
- 发明人: Matthew MACAULEY , Abhishek BATTACHERJEE , Arjun Singh BAINS , Gour DASKHAN
- 申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
- 申请人地址： CA Edmonton, Alberta
- 专利权人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
- 当前专利权人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
- 当前专利权人地址： CA Edmonton, Alberta
- 国际申请： PCT/CA2021/050629 2021.05.05
- 进入国家日期： 2023-11-03
- 主分类号： A61K47/69
- IPC分类号： A61K47/69 ; A61K9/00 ; A61K47/61
摘要：
The present application provides a liposomal composition that multivalently displays a specific glycan ligand, or combination of specific glycan ligands, to specifically target CD33 on microglial cells. Multivalent engagement of CD33 with glycan ligands in the liposomal composition are useful in modulating microglial cell function, particularly as a therapeutic for the preventing, treating or delaying progression of Alzheimer's disease.
信息查询
