专利检索 ap:("THE GOVERNORS OF THE UNIVERSITY OF ALBERTA") AND inv:"Arjun Singh BAINS" 第 1 页

1.

发明公开
LIPOSOMES DISPLAYING A GLYCAN LIGAND FOR CD33 AND THEIR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开

公开(公告)号：US20240238442A1

公开(公告)日：2024-07-18

申请号：US18558999

申请日：2021-05-05

申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA

发明人： Matthew MACAULEY , Abhishek BATTACHERJEE , Arjun Singh BAINS , Gour DASKHAN

IPC分类号： A61K47/69 , A61K9/00 , A61K47/61

CPC分类号： A61K47/6911 , A61K9/0085 , A61K47/61

摘要： The present application provides a liposomal composition that multivalently displays a specific glycan ligand, or combination of specific glycan ligands, to specifically target CD33 on microglial cells. Multivalent engagement of CD33 with glycan ligands in the liposomal composition are useful in modulating microglial cell function, particularly as a therapeutic for the preventing, treating or delaying progression of Alzheimer's disease.