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公开(公告)号：US20240294405A1
公开(公告)日：2024-09-05
申请号：US18440027
申请日：2024-02-13
发明人： Xuehua Zhang , Yawen Gao
IPC分类号： C02F1/46 , A01G9/24 , B01F25/312 , B01F101/00 , C02F1/30
CPC分类号： C02F1/4608 , B01F25/31242 , C02F1/30 , A01G9/243 , B01F2101/305 , B01F2215/0431 , B01F2215/045
摘要： A high efficiency plasma activation system for large scale treatment of liquid including a liquid tank; a pump having an inlet fluidly connected to an outlet of the liquid tank; a self-suction mechanism having a liquid inlet fluidly connected to an outlet of the pump, an air inlet, and an outlet fluidly connected to an inlet of the liquid tank; and a plasma generator having a plasma discharge nozzle positioned adjacent to the air inlet of the self-suction mechanism and configured to discharge gas phase plasma into the air inlet of the self-suction mechanism and introduce micro/nano bubbles (MNBs) into a flow of liquid to be treated to where the MNBs collapse to agitate and impregnate the liquid with a gas, for highly efficient plasma activation of liquid on a large scale as a green and sustainable technology for disinfection in the food industry and agriculture.
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2.发明公开公开(公告)号：US20240238442A1
公开(公告)日：2024-07-18
申请号：US18558999
申请日：2021-05-05
CPC分类号： A61K47/6911 , A61K9/0085 , A61K47/61
摘要： The present application provides a liposomal composition that multivalently displays a specific glycan ligand, or combination of specific glycan ligands, to specifically target CD33 on microglial cells. Multivalent engagement of CD33 with glycan ligands in the liposomal composition are useful in modulating microglial cell function, particularly as a therapeutic for the preventing, treating or delaying progression of Alzheimer's disease.
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公开(公告)号：US20240148767A1
公开(公告)日：2024-05-09
申请号：US18279517
申请日：2022-03-03
发明人： Jason DYCK , Karen Lynn MADSEN
IPC分类号： A61K31/7048 , A61P1/04
CPC分类号： A61K31/7048 , A61P1/04
摘要： A use of empagliflozin for the treatment of ulcerative colitis and Crohn's disease.
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公开(公告)号：US11849540B2
公开(公告)日：2023-12-19
申请号：US17728567
申请日：2022-04-25
发明人： Hyun-Joong Chung , Jana Rieger , Thanh-Giang La , Shide Qiu , Dylan Scott
IPC分类号： H05K1/03 , H05K3/12 , H05K1/02 , A61B5/296 , A61B5/0205 , A61B5/00 , C09D11/10 , H05K1/09 , A61B5/291 , A61B5/297 , A61B5/28 , A61B5/0245 , A61B5/08 , C08K3/08
CPC分类号： H05K1/0283 , A61B5/02055 , A61B5/296 , A61B5/6804 , C09D11/10 , H05K1/095 , H05K3/125 , A61B5/0245 , A61B5/0816 , A61B5/28 , A61B5/291 , A61B5/297 , A61B2562/0209 , A61B2562/0247 , A61B2562/0261 , A61B2562/164 , A61B2562/166 , C08K3/08 , C08K2003/0806 , H05K1/038 , H05K2201/0116 , H05K2201/0215 , H05K2201/0245 , H05K2201/0278 , H05K2201/09263 , H05K2203/1545 , H05K2203/1572
摘要： The development of stretchable, mechanically and electrically robust interconnects by printing an elastic, silver-based composite ink onto stretchable fabric. Such interconnects can have conductivity of 3000-4000 S/cm and are durable under cyclic stretching. In serpentine shape, the fabric-based conductor is enhanced in electrical durability. Resistance increases only ˜5 times when cyclically stretched over a thousand times from zero to 30% strain at a rate of 4% strain per second due to the ink permeating the textile structure. The textile fibers are ‘wetted’ with composite ink to form a conductive, stretchable cladding of the silver particles. The e-textile can realize a fully printed, double-sided electronic system of sensor-textile-interconnect integration. The double-sided e-textile can be used for a surface electromyography (sEMG) system to monitor muscles activities, an electroencephalography (EEG) system to record brain waves, and the like.
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公开(公告)号：US11819822B2
公开(公告)日：2023-11-21
申请号：US16778876
申请日：2020-01-31
发明人： Xing-Fang Li , Zhongshan Liu
IPC分类号： B01J20/24 , B01J20/283 , C07C29/76 , G01N1/40 , G01N1/22 , G01N1/10 , B01J20/10 , B01J20/26 , B01J20/285 , B01J20/288 , B01J20/28 , B01D15/08 , C07K1/16
CPC分类号： B01J20/24 , B01D15/08 , B01J20/103 , B01J20/262 , B01J20/283 , B01J20/285 , B01J20/288 , B01J20/28045 , C07C29/76 , C07K1/16 , G01N1/10 , G01N1/2214 , G01N1/405 , B01J2220/46 , B01J2220/54
摘要： A silica monolith nested in a polymer sponge may be formed by applying a hydrolyzed mixture of siloxanes to a melamine-formaldehyde sponge, and may be used in methods of solid phase extraction.
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6.发明公开公开(公告)号：US20230338919A1
公开(公告)日：2023-10-26
申请号：US17787134
申请日：2020-12-18
CPC分类号： B01J20/041 , C02F1/281 , B01J39/10 , C02F2103/08
摘要： Compositions and methods of preparing sorbent compositions (SCs) and protonated sorbent compositions (PSCs) for use in concentrating lithium from native brines are described. In particular, SCs of the general formula Li1.3-1.6Mn1.6-1.7O4, methods of preparing the SCs and PSCs that have improved properties for lithium extraction and concentration over single and multiple cycles are described.
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公开(公告)号：US11740161B2
公开(公告)日：2023-08-29
申请号：US16770316
申请日：2018-12-07
CPC分类号： G01N1/2205 , G01N13/00 , G09B23/288 , G01N2001/2223 , G01N2001/2288
摘要： A filter for mimicking regional lung deposition is provided that includes filter layers of fibrous filter material stacked coaxially and an outer ring portion encircling the fibrous filter material and securing the filter layers together. The fibrous filter material is formed for fibers having a fiber diameter, and the filter has a tunable filter efficiency. A regional lung deposition system capable of measuring constant flow or variable flow is provided that includes a throat simulation device, a filter housing downstream of and in fluid communication with the throat simulation device, a breath simulator downstream of and in fluid communication with the filter housing, and a an above-referenced filter positioned within the filter housing. Also provided is a filter housing for use in the regional lung deposition system that includes a conical housing having a small inner diameter at a first end and a large inner diameter at a second end.
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公开(公告)号：US20230087306A1
公开(公告)日：2023-03-23
申请号：US17873751
申请日：2022-07-26
摘要： The present disclosure relates generally to unconjugated PLGA nanoparticles in the treatment of Alzheimer's Disease. The present disclosure provides a method of treating a subject having Alzheimer's Disease or a tauopathy or suspected of having Alzheimer's Disease or a tauopathy, the method includes administering a therapeutically effective amount of poly(D,L-lactide-co-glycolide) (PLGA) to the subject.
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公开(公告)号：US20220347114A1
公开(公告)日：2022-11-03
申请号：US17770720
申请日：2020-10-23
发明人： Michael OVERDUIN , Mansoore ESMAILI
IPC分类号： A61K9/51 , C08F212/08
摘要： Amphiphilic copolymers and compositions including amphiphilic copolymers. The amphiphilic copolymers include modified maleimide subunits, for example, as illustrated by the structures of Formula IA and Formula IB. The compositions form water-soluble complexes upon association with biological material wherein such biological material can include lipids or membrane proteins. Methods for producing, purifying, analyzing, and using the compositions and complexes are provided.
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公开(公告)号：US20220306603A1
公开(公告)日：2022-09-29
申请号：US17596491
申请日：2020-06-12
发明人： Frederick WEST , Jack TUSZYNSKI , Michael WEINFELD , Khaled Hassan BARAKAT , Ahmed H. ELMENOUFY , Francesco GENTILE , Feridoun KARIMI-BUSHERI , Claudia WEILBEER
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04 , C07D413/14
摘要： The current application relates to pyronaridine or 6-chloro-2-methoxyacridine analogs having binding affinity for the ERCC1-XPF hetero-dimerization interface. The compounds can be used for targeting DNA repair in tumor cells via ER-CC1-XPF inhibition, therefore improving the therapeutic benefit of irradiation or other cancer treatment, or reducing the dosage and adverse effects associated with such treatment.
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