A braking system for a motorcycle has a first braking device operatively connected to a first wheel of the motorcycle and having a first hydraulic supply circuit, a first electric actuator operatively connected to a first electrically or electro-mechanically actuated piston, and a first interface port operatively connected to a first hydraulic device provided with a first manually actuated piston subdivided into a first direct piston and a first indirect piston hydraulically connected to the first hydraulic supply circuit through a first by-pass duct. A hydraulic fluid reservoir is connected to the first hydraulic device by an upstream connection duct of the first indirect piston and a downstream connection duct of the first indirect piston. A processing and control unit is programmed so that, upon actuation of the first interface port, the first electrically or electro-mechanically actuated piston translates so as to occlude the first by-pass duct, fluidically disconnect the first manually actuated piston from the first hydraulic supply circuit, and simultaneously actuate the first braking device.