A method for a responder bus node is described herein. In accordance with one embodiment, the method includes receiving a first frame over a first data channel of a serial bus, wherein the first frame comprises at least a first header field with first header data and a first payload field with first payload data. The method further includes checking whether a first address, which is based on the first header data, is equal to a predetermined address. When the first address is equal to the predetermined address, a read operation is performed using a second address, which is based on the first payload data, and, when the first address is not equal to the predetermined address, a write operation is performed using the first address and the payload data. Furthermore, a corresponding method for a commander bus node, as well as a respective responder and commander bus node are described.